Staphylococcus aureus CC398 Lineage of the Human Clade Isolated from Bloodstream Infection and Colonization and Spread among Brazilian Patients Hospitalized during the COVID-19 Pandemic.

Thaís Campos Macharete, Tamara Lopes Rocha de Oliveira, Gabriel Freire Igari, Bruna Marques de Souza, Simone Aranha Nouér, Fernanda Sampaio Cavalcante, Kátia Regina Netto Dos Santos

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Article in Current microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Thaís Campos Macharete *Departamento de Microbiologia Médica, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Tamara Lopes Rocha de Oliveira *Departamento de Microbiologia Médica, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Gabriel Freire IgariDepartamento de Microbiologia Médica, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Bruna Marques de SouzaDepartamento de Microbiologia Médica, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Simone Aranha NouérDepartamento de Doenças Infecciosas e Parasitárias, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Fernanda Sampaio CavalcanteDepartamento de Clínica Médica, Instituto de Ciências Médicas, Centro Multidisciplinar de Macaé, Universidade Federal do Rio de Janeiro, Macaé, Brazil.

Kátia Regina Netto Dos SantosDepartamento de Microbiologia Médica, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. santoskrn@micro.ufrj.br.

Funding

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6 · The paper itself

Abstract

Community lineages of Staphylococcus aureus emerging in hospitals, such as CC398, have raised concerns. S. aureus CC398 isolates from bloodstream infections (BSI) and nasal colonization of hospitalized patients, during the COVID-19 pandemic, between March/2020 and September/2021, were characterized for antimicrobial susceptibility by disk diffusion test. Spa types and Sequence Type (ST) were analyzed by PCR/sequencing, and genes of resistance, virulence, and human immune evasion cluster (IEC) were accessed by PCR. Of a total of 118 CC398 isolates, 104 were from nasal swabs (4 MRSA and 100 MSSA), and 14 MSSA were from BSI. Forty (33.9%) patients presented COVID-19, and prior antimicrobial use was common among those colonized (p < 0.05). High resistance rates were found for penicillin (PEN, 92.4%), erythromycin (ERY, 95.8%), clindamycin (CLI, 90.7%) and gentamicin (GEN, 51.7%), and the iMLS

Indexed as

BacteremiaCOVID-19Staphylococcal InfectionsStaphylococcus aureusAdultAgedAged, 80 and overAnti-Bacterial AgentsBrazilDrug Resistance, Multiple, BacterialFemaleHumansMaleMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMiddle AgedAnti-Bacterial Agents

Identifiers

PMID42377565

DOI10.1007/s00284-026-04996-x

PMCPMC13319229

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