ReviewArchives of microbiology2026
Stage-Specific carcinogenic mechanisms and intervention strategies for pks
Review in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Colorectal cancer (CRC) incidence is increasing in many regions, particularly among individuals younger than 50 years. The gut microbiota has emerged as an important regulator of CRC development and treatment response. Among microbial factors, Escherichia coli (E. coli) strains harboring the polyketide synthase (pks) gene island are of particular interest because they produce the genotoxin colibactin. Colibactin induces DNA damage and characteristic mutational signatures, suggesting a potential role in CRC evolution. Rather than acting as a single carcinogenic factor, pks⁺ E. coli-associated carcinogenesis can be viewed as a host-microbe interaction-driven, multistage process involving bacterial colonization, colibactin biosynthesis, DNA damage, mutation accumulation, cellular fate remodeling, microenvironmental amplification, host susceptibility, and clonal expansion. This review summarizes stage-specific intervention strategies, including control of carcinogenic bacteria, blockade of virulence factors, modulation of host responses, microenvironment remodeling, and integration with conventional therapies, providing a framework for precision CRC prevention and treatment.
Indexed as
Identifiers
42377564What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.