SynthesisJournal of artificial organs : the official journal of the Japanese Society for Artificial Organs2026
Outcomes of donation after circulatory death heart transplant using normothermic regional perfusion: a systematic review and meta-analysis.
Synthesis in Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
This systematic review and meta-analysis aim to synthesize evidence comparing normothermic regional perfusion (NRP) and direct procurement and perfusion (DPP) in donation after circulatory death (DCD) heart transplantation, providing evidence-based guidance for optimizing donor heart procurement and transplantation protocols. A systematic literature review was conducted following PRISMA guidelines. PubMed, Embase, the Cochrane Library, and the International Clinical Trials Registry Platform were systematically searched. Two reviewers independently applied eligibility criteria, evaluated quality, and extracted data. The primary outcome was the 30-day survival rate. The 30-day survival rates for NRP and DPP patients were 96.58% and 94.79%, respectively (odds ratio [OR]: 1.52, 95% confidence interval [CI] 1.06-2.17, P = 0.02). Severe primary graft dysfunction (PGD) rates for NRP and DPP patients were 7.90% and 14.03%, respectively (P = 0.002), while the combined rate of none/mild PGD was 86.36% and 85.84% for each group. The cumulative postoperative extracorporeal membrane oxygenation rate for NRP patients was 6.54%, compared to 17.18% for DPP patients (P = 0.0001). The postoperative intra-aortic balloon pump rate for NRP patients was 9.09%, compared to 17.78% for DPP patients (P = 0.35). NRP patients had a higher likelihood of being discharged home than DPP patients (P = 0.36), while NRP patients had a lower likelihood of being discharged from the intensive care unit than DPP patients (P = 0.71). NRP was associated with higher 30-day survival, which is a promising clinical approach in the application of DCD donor hearts.
Indexed as
Identifiers
42377563What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.