SynthesisSurgical endoscopy2026
Efficacy and safety of clipping prior to cyanoacrylate embolization in gastric varices: a single-arm systematic review and meta-analysis.
Synthesis in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Gastric varices: a contemporary review of vascular anatomy and therapeutic strategies.BMJ open gastroenterology · 2026Review
- Comment on: "Preliminary research on the effectiveness and safety of metal clip-assisted endoscopic variceal ligation in the treatment of gastric varices".Therapeutic advances in gastroenterology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGastric variceal bleeding is a life-threatening complication of portal hypertension. Cyanoacrylate injection is the standard endoscopic treatment that carries a significant risk of ectopic embolization, particularly in patients with gastrorenal shunts. Adding endoscopic clips before injection may enhance safety and efficacy, yet evidence remains limited. This study evaluates the safety and effectiveness of clip-assisted cyanoacrylate injection (clip-ECI). METHODOLOGY: A systematic search was conducted on PubMed, Web of Science, CINAHL, Embase, Google Scholar, and the Cochrane Library on October 9, 2025, following the PRISMA 2020 guidelines. The protocol was registered on PROSPERO (CRD420251166002). The primary outcome was rebleeding. Secondary outcomes included technical success, adverse events, ectopic embolism, and procedure-related mortality. Meta-analysis was performed using R version 3.4.3 (R Core Team) with a random-effects model expressed as proportions and 95% confidence intervals (CIs).
resultsSix studies involving 465 participants treated with clip-ECI were included, four in the meta-analysis due to overlapping populations. Most participants were middle-aged males with cirrhosis from hepatitis B, presenting with GOV2 or IGV1 gastric varices; 41.7-100% had gastrorenal shunts. The pooled technical success rate was 99% (95% CI 0.97-1.0; p = 0.97; I
conclusionClip-ECI appears highly effective with low rebleeding and embolic complication rates, supporting its safety for gastric varices, particularly in patients with gastrorenal shunts. Large multicenter randomized trials are needed to strengthen these findings and establish clinical protocols.
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