Evidence map›Paper›PMID 42377497›Full record

SynthesisAesthetic plastic surgery2026

Safety Profile of Facial Cosmetic Surgery Under Local Anesthesia, with or without Sedation: A Systematic Review and Meta-analysis.

Emmanuel Giannas, Luke S Jones, Maria Kalogeromitros, Franklin R Gergoudis, Georgios Karamitros, Ricardo A Torres-Guzman, Allen Gabriel, Wesley P Thayer, Galen Perdikis, Patrick Assi

Abstract readSystematic ReviewMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Aesthetic plastic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Emmanuel GiannasDepartment of Plastic Surgery, Vanderbilt University Medical Center, S-2221, Medical Center North, Nashville, TN, 37212, USA. manolis.giannas@gmail.com.
Luke S JonesDepartment of Plastic Surgery, Vanderbilt University Medical Center, S-2221, Medical Center North, Nashville, TN, 37212, USA.
Maria KalogeromitrosBrody School of Medicine, East Carolina University, Greenville, NC, USA.
Franklin R GergoudisDepartment of Plastic Surgery, Vanderbilt University Medical Center, S-2221, Medical Center North, Nashville, TN, 37212, USA.
Georgios KaramitrosDepartment of Plastic Surgery, Vanderbilt University Medical Center, S-2221, Medical Center North, Nashville, TN, 37212, USA.
Ricardo A Torres-GuzmanDepartment of Plastic Surgery, Vanderbilt University Medical Center, S-2221, Medical Center North, Nashville, TN, 37212, USA.
Allen GabrielDepartment of Plastic Surgery, Vanderbilt University Medical Center, S-2221, Medical Center North, Nashville, TN, 37212, USA.
Wesley P ThayerDepartment of Plastic Surgery, Vanderbilt University Medical Center, S-2221, Medical Center North, Nashville, TN, 37212, USA.
Galen PerdikisDepartment of Plastic Surgery, Vanderbilt University Medical Center, S-2221, Medical Center North, Nashville, TN, 37212, USA.
Patrick AssiDepartment of Plastic Surgery, Vanderbilt University Medical Center, S-2221, Medical Center North, Nashville, TN, 37212, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionFacial aesthetic surgery is increasingly performed under local anesthesia, with or without sedation, in office-based settings. This systematic review and meta-analysis aimed to determine the safety profile of such procedures by measuring the incidence of complications following facial cosmetic surgery under local anesthesia, with or without sedation.

methodsA systematic review of the literature was performed in line with the PRISMA guidelines. The databases PubMed, Embase, Scopus, CINAHL, and Web of Science were searched. Studies reporting on complications following facial cosmetic surgery performed in outpatient settings under local anesthesia, with or without sedation, were included. The pooled weighted incidence of complications was calculated using a random-effects inverse variance model with Freeman-Tukey transformation.

resultsTwelve studies were included, with a procedure pool of 3283. The incidence of total complications was 5.6%, 95% CI [2.8, 9.3]. The incidence of major complications was 1.6%, 95% CI [0.1, 4.3], while minor complications occurred in 3.7%, 95% CI [2.0, 5.7], of cases. Combined facial aesthetic procedures were uncommon, with 9% of patients undergoing multiple procedures in the same operative setting.

conclusionFacial cosmetic surgery under local anesthesia, with or without sedation, appears to be associated with a low incidence of complications. Combined procedures were uncommon, indicating that operative scope in these settings is generally limited. Substantial heterogeneity among studies underscores the need for standardized definitions of complications, anesthetic protocols, and evidence-based patient selection criteria. Future research should focus on developing these frameworks and incorporating validated outcome measures to further optimize safety and patient satisfaction. LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Indexed as

Anesthesia, LocalCosmetic TechniquesFacePlastic Surgery ProceduresProcedural SedationSurgery, PlasticEstheticsHumansPatient SafetyPatient SatisfactionPostoperative ComplicationsAnesthesiaFacial aesthetic surgeryPatient safety

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.