Evidence map›Paper›PMID 42377388›Full record

ArticleJapanese journal of ophthalmology2026

Utility of liquid-based cytology and cell block obtained by vitrectomy under infusion to diagnose vitreoretinal lymphoma.

Rintaro Ohe, Sonoka Oyanagi, Eriko Inamura, Takumi Kitaoka, Takanobu Kabasawa, Kazushi Suzuki, Naoya Uchiyama, Ami Shida, Toshinori Suzuki, Keita Togashi and 1 more

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Article in Japanese journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Rintaro OheDepartment of Pathology Faculty of Medicine, Yamagata University, Yamagata, Japan.
Sonoka OyanagiDepartment of Ophthalmology and Visual Sciences Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata, 990-9585, Japan.
Eriko InamuraDepartment of Ophthalmology and Visual Sciences Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata, 990-9585, Japan.
Takumi KitaokaDepartment of Pathology Faculty of Medicine, Yamagata University, Yamagata, Japan.
Takanobu KabasawaDepartment of Pathology Faculty of Medicine, Yamagata University, Yamagata, Japan.
Kazushi SuzukiDepartment of Pathology Faculty of Medicine, Yamagata University, Yamagata, Japan.
Naoya UchiyamaDepartment of Pathology Faculty of Medicine, Yamagata University, Yamagata, Japan.
Ami ShidaDepartment of Pathology, Yamagata University Hospital, Yamagata, Japan.
Toshinori SuzukiDepartment of Pathology, Yamagata University Hospital, Yamagata, Japan.
Keita TogashiDepartment of Ophthalmology and Visual Sciences Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata, 990-9585, Japan.
Yutaka KanekoDepartment of Ophthalmology and Visual Sciences Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata, 990-9585, Japan. y-kaneko@med.id.yamagata-u.ac.jp.ORCID http://orcid.org/0000-0003-4700-9793

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo confirm the definitive diagnostic method of vitreoretinal lymphoma by vitrectomy under infusion. STUDY

designRetrospective, pathological analysis

methodsTwenty-two patients participated in this study; 29 vitreous samples were obtained under infusion. Liquid-based cytology (LBC) was performed by targeting areas with a high cell concentration while observing the surgical field under infusion. Cell block analysis was performed by the vitreous cell components in the intraocular irrigating fluid.

resultsOur vitreous sample collection did not result in adverse events. In LBC samples, atypical large lymphoid cells were identified in 89.7%. These samples contained between 30 and over 10,000 atypical large lymphoid cells. Necrosis was observed in 76.9% in the background of LBC samples. In cell block samples, atypical large lymphoid cells were identified in 87.0%. Immunohistochemical staining revealed the following immunophenotypes for the lymphoid cells: CD20 (100%), CD79a (100%), CD10 (0%), BCL6 (57.1%), MUM1 (85.7%), and Ki-67 LI 66.3±12.7%.

conclusionThis method ensures safety and high diagnostic accuracy, thereby contributing to the definitive diagnosis of vitreoretinal lymphoma.

Indexed as

CytodiagnosisIntraocular LymphomaLymphomaRetinal NeoplasmsVitrectomyVitreous BodyAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedRetrospective StudiesCell blockLiquid-based cytologyVitrectomy under infusionVitreoretinal lymphoma (VRL)

Identifiers

PMID42377388
PMCPMC13615911

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