Evidence map›Paper›PMID 42377283›Full record

ReviewToxicological sciences : an official journal of the Society of Toxicology2026

Aryl hydrocarbon receptor nuclear translocator 2: a forgotten per-ARNT-Sim transcription factor.

Israt Jahan, Yadeliz A Serrano Matos, Arul Jayaraman, Aditya D Joshi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Toxicological sciences : an official journal of the Society of Toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Israt JahanDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, United States.
Yadeliz A Serrano MatosDepartment of Chemical Engineering, Texas A&M University, College Station, TX 77843, United States.
Arul JayaramanDepartment of Chemical Engineering, Texas A&M University, College Station, TX 77843, United States.
Aditya D JoshiDepartment of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX 77843, United States.ORCID 0000-0002-5208-5144

Funding

Regulatory Science in Environmental Health and ToxicologyT32ES026568 · NIEHS · TEXAS A&M UNIVERSITY · PI Weihsueh A Chiu, Natalie M Johnson · 2016 to 2026
$3.8M
Novel Mechanism of aryl hydrocarbon receptor-mediated differential gene regulationR01DK122028 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Aditya D Joshi · 2019 to 2026
$2.3M
NIDDK NIH HHS R01 DK122028NIEHS NIH HHS T32 ES026568Ray Nesbitt Chair endowment
6 · The paper itself

Abstract

Aryl hydrocarbon receptor nuclear translocator 2 is a member of the basic helix-loop-helix/Per-ARNT-Sim family of transcription factors involved in responding to various environmental, metabolic, and chemical signals. Initially known for its involvement in neurodevelopment, ARNT2 is now recognized as an essential binding partner for other transcription factors, including single-minded homologs 1 and 2, neuronal PAS domain protein 4, hypoxia-inducible factor 1, and plausibly Aryl hydrocarbon receptor to regulate stress adaptation, synaptic plasticity, immune signaling, and energy balance pathways. The role of ARNT2 has also been implicated in a plethora of pathologies, including inflammation, cardiovascular diseases, neurological disorders, metabolic diseases, and cancers. This review summarizes the current knowledge of ARNT2's structure, regulation, interacting partners, and its toxicopathological significance. A better understanding of ARNT2 biology may open new avenues for its characterization as a molecular target and designing novel therapeutic strategies across multiple diseases.

Indexed as

Aryl Hydrocarbon Receptor Nuclear TranslocatorBasic Helix-Loop-Helix ProteinsAnimalsHumansSignal TransductionARNT2 protein, humanAryl Hydrocarbon Receptor Nuclear TranslocatorBasic Helix-Loop-Helix ProteinsARNT2cancercardiometabolic diseasesnuclear receptorsPer/ARNT/Sim transcription factors

Identifiers

PMID42377283
PMCPMC13371768

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.