Evidence map›Paper›PMID 42377118›Full record

Trial reportAging2026

Short-term responsiveness of DNA methylation-based aging biomarkers to a multimodal intervention comprising exercise and dietary guidance involving daily consumption of yogurt containing

Tatsuki Nishimura, Ayako Horigome, Miyuki Tanaka, Yukihiro Hishida, Toshitaka Odamaki

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tatsuki NishimuraBiotics Research Institute, R&D Division, Morinaga Milk Industry Co., Ltd., Zama, 252-8583, Japan.
Ayako HorigomeBiotics Research Institute, R&D Division, Morinaga Milk Industry Co., Ltd., Zama, 252-8583, Japan.
Miyuki TanakaFood Function Research Institute, R&D Division, Morinaga Milk Industry Co., Ltd., Zama, 252-8583, Japan.
Yukihiro HishidaBiotics Research Institute, R&D Division, Morinaga Milk Industry Co., Ltd., Zama, 252-8583, Japan.
Toshitaka OdamakiBiotics Research Institute, R&D Division, Morinaga Milk Industry Co., Ltd., Zama, 252-8583, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging-related chronic diseases are driven by multiple mechanisms, motivating efforts to develop feasible interventions that can attenuate biological aging. DNA methylation-based epigenetic clocks, particularly measures of the pace of aging such as DunedinPACE, are sensitive to relatively short-term changes in aging processes. However, evidence from randomized controlled trials remains limited. We conducted a randomized controlled trial to test a 12-week multimodal lifestyle intervention comprising exercise and dietary guidance involving daily consumption of yogurt containing

Indexed as

AgingBifidobacterium longumDNA MethylationExerciseOverweightProbioticsYogurtAgedBiomarkersHumansMaleMiddle AgedBiomarkersBifidobacterium longum BB536DNA methylation clockDunedinPACEMulticomponent lifestyle intervention

Identifiers

PMID42377118

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.