Evidence map›Paper›PMID 42377112›Full record

ArticleAntimicrobial agents and chemotherapy2026

Characterization of GUA-1, a chromosomally encoded ESBL from

Saoussen Oueslati, Nadia Jaidane, Reva Nermont, Delphine Girlich, Nahed Al Laham, Lamia Tilouche, Wejdene Mansour, Marisa Haenni, Bogdan I Iorga, Thierry Naas

Abstract read
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In one paragraph

Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Saoussen OueslatiTeam 'Resist', UMR1184 IDMIT (INSERM, Université Paris-Saclay, CEA), Faculty of Medicine, Le Kremlin-Bicêtre, France.
Nadia JaidaneLaboratory of Metabolic Biophysics and Applied Pharmacology (LR12ES02), Department of Biophysics, Faculty of Medicine Ibn El Jazzar of Sousse, University of Sousse, Sousse, Tunisia.
Reva NermontTeam 'Resist', UMR1184 IDMIT (INSERM, Université Paris-Saclay, CEA), Faculty of Medicine, Le Kremlin-Bicêtre, France.
Delphine GirlichTeam 'Resist', UMR1184 IDMIT (INSERM, Université Paris-Saclay, CEA), Faculty of Medicine, Le Kremlin-Bicêtre, France.
Nahed Al LahamTeam 'Resist', UMR1184 IDMIT (INSERM, Université Paris-Saclay, CEA), Faculty of Medicine, Le Kremlin-Bicêtre, France.
Lamia TiloucheLaboratory of Metabolic Biophysics and Applied Pharmacology (LR12ES02), Department of Biophysics, Faculty of Medicine Ibn El Jazzar of Sousse, University of Sousse, Sousse, Tunisia.
Wejdene MansourLaboratory of Metabolic Biophysics and Applied Pharmacology (LR12ES02), Department of Biophysics, Faculty of Medicine Ibn El Jazzar of Sousse, University of Sousse, Sousse, Tunisia.
Marisa HaenniANSES-Université de Lyon, Unité Antibiorésistance et Virulence Bactériennes, Lyon, France.
Bogdan I IorgaUniversité Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles (ICSN), Gif-sur-Yvette, France.ORCID 0000-0003-0392-1350
Thierry NaasTeam 'Resist', UMR1184 IDMIT (INSERM, Université Paris-Saclay, CEA), Faculty of Medicine, Le Kremlin-Bicêtre, France.ORCID 0000-0001-9937-9572

Funding

Agence Nationale de la Recherche ANR-20-PAMR-0010Assistance Publique-Hôpitaux de Paris ResistInstitut National de la Santé et de la Recherche Médicale UMR1184Tunisian Ministry of Higher Education JPI-AMR- PAIRWISEUniversité Paris-Saclay Healthi
6 · The paper itself

Abstract

Putative novel β-lactamase-encoding genes are increasingly identified in whole-genome sequencing (WGS) data, often without phenotypic or biochemical characterization. Here, we characterized the chromosome-encoded GUA-1 Ambler class A β-lactamase from the clinical isolate

Indexed as

Bacterial Proteinsbeta-LactamasesChromosomes, BacterialPseudomonasAnti-Bacterial AgentsCefotaximeClavulanic AcidEscherichia coliMicrobial Sensitivity TestsPseudomonas aeruginosaTazobactamThird Generation CephalosporinsAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesCefotaximeClavulanic AcidTazobactamThird Generation Cephalosporinscephalosporinaseclass Aextended spectrum beta-lactamasePseudomonas sp

Identifiers

PMID42377112
PMCPMC13436361

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.