Evidence map›Paper›PMID 42377036›Full record

ArticleMicrobiology spectrum2026

PHGDH restricts porcine reproductive and respiratory syndrome virus replication by sustaining cellular antioxidant capacity and redox homeostasis.

Zhangping Yu, Qiongqiong Zhou, Peng Gao, Yongning Zhang, Xinna Ge, Jun Han, Xin Guo, Lei Zhou, Hanchun Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhangping YuState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.ORCID 0000-0003-0154-4758
Qiongqiong ZhouState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.
Peng GaoState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.
Yongning ZhangState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.ORCID 0000-0002-0134-2761
Xinna GeState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.ORCID 0000-0002-5368-9687
Jun HanState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.ORCID 0000-0002-7104-7223
Xin GuoState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.ORCID 0000-0002-6451-0478
Lei ZhouState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.ORCID 0000-0002-8837-3965
Hanchun YangState Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.ORCID 0000-0003-3359-3925

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) remains a major threat to the swine industry. Although redox imbalance and oxidative stress are known to favor PRRSV infection, the host determinants that preserve redox homeostasis during PRRSV replication remain insufficiently defined. Here, we identify phosphoglycerate dehydrogenase (PHGDH), the rate-limiting enzyme of the

Indexed as

AntioxidantsPhosphoglycerate DehydrogenasePorcine Reproductive and Respiratory SyndromePorcine respiratory and reproductive syndrome virusVirus ReplicationAnimalsCell LineHomeostasisHost-Pathogen InteractionsMacrophages, AlveolarOxidation-ReductionOxidative StressReactive Oxygen SpeciesSwineAntioxidantsPhosphoglycerate DehydrogenaseReactive Oxygen Speciesmitochondrial damageoxidative stressPHGDHPRRSVROSviral replication

Identifiers

PMID42377036
PMCPMC13435642

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.