Evidence map›Paper›PMID 42377023›Full record

ArticlemSphere2026

Cysteine-S-nitrosylation inhibits ROP5-mediated immune evasion in

S L Lempke, P DiMare, B Nichols, L F Fitzsimmons, A Chaudhry, V C Grebe, M L Reese, S E Ewald

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

S L LempkeDepartment of Microbiology, Immunology, and Cancer Biology at the Carter Immunology Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
P DiMareDepartment of Microbiology, Immunology, and Cancer Biology at the Carter Immunology Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
B NicholsDepartment of Pharmacology, University of Texas, Southwestern Medical Center, Dallas, Texas, USA.
L F FitzsimmonsDepartment of Microbiology, Immunology, and Cancer Biology at the Carter Immunology Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
A ChaudhryDepartment of Microbiology, Immunology, and Cancer Biology at the Carter Immunology Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
V C GrebeDepartment of Microbiology, Immunology, and Cancer Biology at the Carter Immunology Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
M L ReeseDepartment of Pharmacology, University of Texas, Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0001-9401-9594
S E EwaldDepartment of Microbiology, Immunology, and Cancer Biology at the Carter Immunology Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA.ORCID 0000-0002-5327-7578

Funding

Innate Inflammatory Control of CachexiaR35GM138381 · NIGMS · UNIVERSITY OF VIRGINIA · PI Sarah E. Ewald · 2020 to 2026
$2.9M
Burroughs Wellcome Fund G-1021959NIGMS NIH HHS R35 GM138381NIGMS NIH HHS R35GM138381Welch Foundation I-2075-20240404
6 · The paper itself

Abstract

Reactive nitrogen species (RNS) are a mechanism to control microbial infections conserved across the host species of the obligate intracellular parasite IMPORTANCE: RNS are necessary for cell-autonomous immunity to

Indexed as

CysteineImmune EvasionProtozoan ProteinsToxoplasmaAnimalsFemaleInterferon-gammaMacrophagesMiceMice, Inbred C57BLMice, KnockoutNitric Oxide Synthase Type IIProtein Processing, Post-TranslationalToxoplasmosisCysteineInterferon-gammaNitric Oxide Synthase Type IIProtozoan Proteinscell-autonomous immunityinnate immunityiNOSinterferonsmacrophagesnitric oxide synthasenitrosylationRNSToxoplasma gondii

Identifiers

PMID42377023
PMCPMC13410961

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.