Evidence map›Paper›PMID 42376993›Full record

SynthesisProceedings (Baylor University. Medical Center)2026

The risk of primary lung cancer in ANCA-associated vasculitis: systematic review and meta-analysis.

Nattanicha Chaisrimaneepan, Pitchaporn Yingchoncharoen, Tulaton Sodsri, Natnicha Jakramonpreeya, Kenneth M Nugent

Abstract readSystematic ReviewMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Proceedings (Baylor University. Medical Center), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. ANCA-associated vasculitis: addressing the emerging risk of lung cancer.Proceedings (Baylor University. Medical Center) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nattanicha ChaisrimaneepanDepartment of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.ORCID 0000-0002-3183-7853
Pitchaporn YingchoncharoenDivision of Rheumatology, Department of Medicine, University of Missouri, Columbia, Missouri, USA.
Tulaton SodsriDepartment of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
Natnicha JakramonpreeyaChakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Samut Prakan, Thailand.
Kenneth M NugentDepartment of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic inflammatory disorder that affects small blood vessels. However, the association between AAV and lung cancer risk remains uncertain. We performed a systematic review and meta-analysis to evaluate the relationship between AAV and the risk of lung cancer.

methodsWe systematically searched PubMed, Embase, Scopus, and Web of Science from inception through March 2025. Studies reporting relative risks (RRs), odds ratios (ORs), hazard ratios (HRs), or standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were included. SIRs were used to estimate relative risk versus the general population. Pooled RR and 95% CI were calculated using a random-effects model (DerSimonian and Laird). Heterogeneity and publication bias were assessed.

resultsThirteen studies (11 cohort, 2 case-control) including 8004 participants were analyzed. The mean age at diagnosis was 58.83 ± 16.99 years, with 49.68% male. Follow-up ranged from 2 to 26 years. The pooled RR for lung cancer was 2.08 (95% CI, 1.52-2.83), indicating increased risk. Moderate heterogeneity was observed (I

conclusionThere is an increased risk of lung cancer in patients with AAV. Further studies are warranted to better elucidate the underlying mechanisms and guide appropriate screening strategies.

Indexed as

Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisLung NeoplasmsFemaleHumansMaleMiddle AgedRisk FactorsAntineutrophil cytoplasmic antibodygranulomatosis with polyangiitislung cancermicroscopic polyangiitissmall vessel vasculitis

Identifiers

PMID42376993
PMCPMC13523952

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.