ArticleACR open rheumatology2026
Exploring the Shared Genetic Basis of Age at Menopause and Osteoarthritis.
Article in ACR open rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
objectiveThe relationship between age at menopause and osteoarthritis (OA) remains unclear.
methodsThe genetic commonalities between age at menopause and OA were investigated using data from publicly accessible genome-wide association studies. A variety of methods were employed in this exploration, such as linkage disequilibrium score regression (LDSC), high-definition likelihood, LAVA, pleiotropic analysis under composite null hypothesis, and summary-databased Mendelian randomization. Additionally, causal relationships were probed through the application of Mendelian randomization techniques.
resultsA significant negative genetic correlation was identified between age at menopause and OA, with a genetic correlation coefficient of -0.115 and a P value of 1.79 × 10
conclusionThis study's results provide a deeper comprehension of the genetic underpinnings and complex interplay between age at menopause and OA. It contributes novel perspectives for the discovery of shared genetic-based therapeutic targets, highlighting the value of understanding their common genetic framework for developing future treatments.
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