Evidence map›Paper›PMID 42376686›Full record

ArticleChembiochem : a European journal of chemical biology2026

Working So Hard: Double-Stranded RNAs That Can Perform Both Gene Activation and Gene Silencing.

Virginia Wing-Nam Chiu, Matthew Lawrence Hammill, Marwah Elabed, Sierra Varley, Yulia Lomonosova, Joseph Hoare, Jon Voutila, Henrik Hansen, Troels Koch, Jean-Paul Desaulniers

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Virginia Wing-Nam ChiuFaculty of Science, Ontario Tech University, Oshawa, Canada.
Matthew Lawrence HammillFaculty of Science, Ontario Tech University, Oshawa, Canada.
Marwah ElabedFaculty of Science, Ontario Tech University, Oshawa, Canada.
Sierra VarleyFaculty of Science, Ontario Tech University, Oshawa, Canada.
Yulia LomonosovaMiNA Therapeutics, London, UK.
Joseph HoareMiNA Therapeutics, London, UK.
Jon VoutilaMiNA Therapeutics, London, UK.
Henrik HansenMiNA Therapeutics, London, UK.
Troels KochMiNA Therapeutics, London, UK.
Jean-Paul DesaulniersFaculty of Science, Ontario Tech University, Oshawa, Canada.ORCID https://orcid.org/0000-0002-9596-4552

Funding

Natural Sciences and Engineering Research Council of Canada RGPIN-2025-05248
6 · The paper itself

Abstract

Double-stranded RNAs (dsRNAs) are powerful tools with therapeutic potential because they can upregulate or downregulate proteins of interest within biological systems. Small activating RNAs (saRNAs) are a type of dsRNA, identical in structure and composition to small interfering RNAs (siRNAs). We previously observed that RNA duplexes with modifications such as 2'-O-methyl (2'-O-Me), 2'-fluoro (2'-F), locked (LNA), and unlocked nucleic acids (UNA), and a C

Indexed as

Gene SilencingRNA, Double-StrandedHumansMembrane ProteinsRNA InterferenceRNA, Small InterferingMembrane ProteinsRNA, Double-StrandedRNA, Small Interferingchemical modificationoligonucleotidesRNARNA activationRNA interferencesaRNAsiRNA

Identifiers

PMID42376686
PMCPMC13316730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.