ArticleOpen veterinary journal2025
NT-proBNP versus cardiac troponin-I (cTnI) for the early detection of cardiac diseases in dogs with other cardiographic findings.
Article in Open veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Heart diseases are common in dogs, geriatric, overweight, to obese individuals, with metabolic problems, lack of nutrition, and breed problems. NT-proBNP and cardiac troponin-I (cTnI) are selected for the diagnosis of heart damage in early detection. Both of these biomarkers have another function. This study compared NT-proBNP with cTnI for the early detection of cardiac diseases in dogs. Aim: This study compared NT-proBNP with cTnI levels for the early detection of cardiac diseases in dogs. Methods: A total of five dogs of various breeds, ages, sexes, and body weights were included. All animals underwent a comprehensive diagnostic workup, including a thorough history and physical examination, cardiorespiratory auscultation, and laboratory diagnostics. These diagnostics include blood pressure measurement, thoracic radiography, and echocardiography, which are performed on every patient, and biomarker levels used a commercial kit rapid test ( Results: Four dogs had a cardiac troponin I level of >0.1 ng/ml (abnormal), and 1 dog has a normal cTnI level, but four dogs had a normal NT-proBNP level ≤ 2 ng/ml, but 1 dog has an abnormal level. Every dog has laboratory results based on blood pressure, electrocardiography, X-ray, and echocardiography per case. Based on cardiographic results relevant with cTnI that more sensitive if asymptomatic patients rather than NT-proBNP. Conclusion: cTnI is more sensitive than NT-proBNP, supported by other laboratory examinations to establish a more accurate diagnosis. However, a larger number of case samples is needed to draw a more accurate diagnosis.
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