Evidence map›Paper›PMID 42376518›Full record

ArticleOpen veterinary journal2025

Efficacy of a multivalent inactivated

Wael K Elfeil, Salma Essam, Esraa Mostafa, Doaa E Ismail, Mohamed Fathy, Hend Altaib, Mohamed E Basuony, Ahmed Sedeek, Islam Hisham, Momtaz Wasfy and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wael K ElfeilAvian and Rabbit Medicine Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt.
Salma EssamMEVAC-Middle East for Vaccines, Second Industrial Area, El-Salihya El-Gededa, El-Sharkia, Egypt.
Esraa MostafaMEVAC-Middle East for Vaccines, Second Industrial Area, El-Salihya El-Gededa, El-Sharkia, Egypt.
Doaa E IsmailMEVAC-Middle East for Vaccines, Second Industrial Area, El-Salihya El-Gededa, El-Sharkia, Egypt.
Mohamed FathyAnimal and Poultry Health Department, Desert Research Centre, Cairo, Egypt.
Hend AltaibMEVAC-Middle East for Vaccines, Second Industrial Area, El-Salihya El-Gededa, El-Sharkia, Egypt.
Mohamed E BasuonyMEVAC-Middle East for Vaccines, Second Industrial Area, El-Salihya El-Gededa, El-Sharkia, Egypt.
Ahmed SedeekReference Laboratory for Veterinary Quality Control on Poultry Production (RLQP), Animal Health Research Institute (AHRI), Agricultural Research Center (ARC), Giza, Egypt.
Islam HishamReference Laboratory for Veterinary Quality Control on Poultry Production (RLQP), Animal Health Research Institute (AHRI), Agricultural Research Center (ARC), Giza, Egypt.
Momtaz WasfyMEVAC-Middle East for Vaccines, Second Industrial Area, El-Salihya El-Gededa, El-Sharkia, Egypt.
Walid H KilanyReference Laboratory for Veterinary Quality Control on Poultry Production (RLQP), Animal Health Research Institute (AHRI), Agricultural Research Center (ARC), Giza, Egypt.
Nermeen M Abu-ElalaAquatic Animal Medicine and Management Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Aim: This study assessed the safety and effectiveness of a tetravalent inactivated Methods: Antimicrobial susceptibility was tested for Results: MDR was detected in all isolates, with high resistance to clindamycin, penicillin, ampicillin, tetracycline, and streptomycin. The vaccine was well tolerated with no adverse effects. Vaccinated birds had significantly higher antibody titers, reduced fecal shedding by 14 days post-challenge, and lower liver translocation, with no detectable bacteria by direct plating from day 4 post-challenge. Conclusion: The vaccine demonstrated strong safety, immunogenicity, and efficacy in reducing shedding and systemic dissemination of

Indexed as

Bacterial SheddingChickensPoultry DiseasesSalmonellaSalmonella Infections, AnimalSalmonella VaccinesAnimalsDrug Resistance, Multiple, BacterialFecesSpecific Pathogen-Free OrganismsVaccines, InactivatedSalmonella VaccinesVaccines, InactivatedAntimicrobial resistanceBacterial translocationFecal sheddingFood safetyPoultry vaccineSalmonellaTetravalent vaccine

Identifiers

PMID42376518
PMCPMC13313911

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.