Evidence map›Paper›PMID 42376430›Full record

ArticleJournal of oral microbiology2026

Oral fungal microbiome in gout: composition, cross-kingdom interactions, and effects of intervention.

Menghui Yao, Yingdong Han, Chengjin Huang, Mengmeng Dai, Xiaohan Zhang, Yun Zhang, Xuejun Zeng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of oral microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Menghui YaoDepartment of Family Medicine, Division of General Internal Medicine, Department of Internal Medicine, Peking Union Medical College Hospital, State Key Laboratory of Complex Severe and Rare Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, People's Republic of China.ORCID https://orcid.org/0009-0003-9628-5062
Yingdong HanDepartment of Family Medicine, Division of General Internal Medicine, Department of Internal Medicine, Peking Union Medical College Hospital, State Key Laboratory of Complex Severe and Rare Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, People's Republic of China.
Chengjin HuangDepartment of Family Medicine, Division of General Internal Medicine, Department of Internal Medicine, Peking Union Medical College Hospital, State Key Laboratory of Complex Severe and Rare Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, People's Republic of China.
Mengmeng DaiDepartment of Family Medicine, Division of General Internal Medicine, Department of Internal Medicine, Peking Union Medical College Hospital, State Key Laboratory of Complex Severe and Rare Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, People's Republic of China.
Xiaohan ZhangDepartment of Family Medicine, Division of General Internal Medicine, Department of Internal Medicine, Peking Union Medical College Hospital, State Key Laboratory of Complex Severe and Rare Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, People's Republic of China.
Yun ZhangDepartment of Family Medicine, Division of General Internal Medicine, Department of Internal Medicine, Peking Union Medical College Hospital, State Key Laboratory of Complex Severe and Rare Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, People's Republic of China.
Xuejun ZengDepartment of Family Medicine, Division of General Internal Medicine, Department of Internal Medicine, Peking Union Medical College Hospital, State Key Laboratory of Complex Severe and Rare Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Oral fungi, despite their low abundance, may influence microbial interactions, host responses, and disease progression; however, their role in gout remains poorly understood. Materials and methods: Between March and December 2024, patients with chronic gouty arthritis (CGA), acute gouty arthritis (AGA), and age- and sex-matched healthy controls (HC) were enrolled. Unstimulated saliva underwent ITS2 sequencing. Analyses included Results: A total of 76 participants (35 CGA, 17 AGA, 24 HC) were included. Alpha-diversity showed no significant difference, while Conclusion: This study provides the first characterization of the oral mycobiome in gout, highlighting weakened microbial connectivity and reinforced pathogen associations. Interventions may restore network integrity before compositional normalization, suggesting the oral mycobiome as a potential target in gout.

Indexed as

co-occurrence networkcross-kingdom interactionfollow-upfungal microbiomeGoutITS2 sequencing

Identifiers

PMID42376430
PMCPMC13312830

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.