ArticleOpen veterinary journal2026
Role of the small intestinal submucosa-extracellular matrix grafts powder on regeneration of full-thickness wound in skin of rabbits.
Article in Open veterinary journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Background: Wound healing continues to pose a considerable clinical challenge, especially in the context of surgical intervention, despite numerous treatment options; an ideal solution for wound injuries has yet to be established. Small intestinal submucosa-extracellular matrix (SIS-ECM) has shown potential in regenerative medicine due to its properties that may facilitate tissue repair and wound healing. Aim: This study aims to assess the efficacy of SIS-ECM powder in promoting the healing of full-thickness wounds in the rabbit model, with particular emphasis on focusing on epithelialization rate and inflammatory response reduction. Methods: Twenty clinically healthy adult male rabbits were allocated into two experimental groups. A full-thickness excisional wounds measuring 2 × 2 cm was surgically induced on the dorsal skin of each animal. Group A (control group) received phosphate-buffered saline, whereas Group B (treatment group) was administered SIS-ECM powder. Histopathological evaluation was conducted via biopsy on days 7th, 14th, and 35th post wounding to monitor healing progression. Results: Topical application SIS-ECM powder-significantly accelerated epithelialization by day 21 Conclusion: SIS-ECM powder creates a favorable microenviroment that supports cell growth and differentiation, thereby enhancing the healing process of full-thickness wounds.
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