ArticleOpen veterinary journal2026
Evaluation of acute phase protein, cardiac marker, and antioxidant enzymes in Madura Cattle infected with foot-and-mouth disease.
Article in Open veterinary journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Foot-and-mouth disease (FMD) is a highly contagious viral disease in cloven-hoofed animals and remains a significant cause of economic loss in the livestock sector. In addition to causing characteristic clinical symptoms, FMD infection triggers a systemic inflammatory response and oxidative stress that can alter various biochemical and cardiac parameters. However, information on the biochemical and antioxidant profiles of local Indonesian cattle, particularly Madura cattle, remains limited. Aim: This study aimed to evaluate changes in acute phase proteins (APPs), cardiac markers, and antioxidant enzyme activity in Madura cattle naturally infected with FMD and to analyze the relationships between these biochemical parameters during the infection and recovery phases. Methods: Ten 2.5 ± 0.5-year-old male Madura cattle clinically diagnosed with FMD had blood samples taken twice during the infection phase (days 3-7) and the recovery phase (days 28-30). The biochemical parameters analyzed included creatine kinase (CK), CK-myocardial band (CK-MB), lactate dehydrogenase (LDH), cardiac troponin I (cTn-I), haptoglobin (Hp), C-reactive protein (CrP), superoxide dismutase (SOD), glutathione peroxidase (GPx), and malondialdehyde (MDA) using enzyme-linked immunosorbent assay and spectrophotometry methods. Data were analyzed using paired Results: There were significant differences ( Conclusion: FMD infection in Madura cattle causes physiological changes characterized by increased cardiac biomarkers and APPs and decreased antioxidant enzyme activity. The positive relationship between Hp and GPx reflects the link between the inflammatory process and oxidative stress during recovery. The combination of APP parameters and antioxidant enzymes can be used as biochemical indicators to assess the severity and health status of FMD-infected cattle.
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