ArticleSaudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
Keratitis patterns in patients with human immunodeficiency virus: A 10-year retrospective study.
Article in Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo investigate the relationship between human immunodeficiency virus (HIV) disease markers, types of keratitis, and sociodemographic factors.
methodsThis retrospective epidemiologic study examines HIV-positive patients diagnosed with keratitis over the past 10 years. A chart review was conducted to confirm diagnosis and extract key demographic data (sex, age at keratitis diagnosis, race, and zip codes) and disease metrics (type of keratitis, infectious organism, antimicrobials used, CD4 count, and antiretroviral therapy [ART] adherence). The distribution of keratitis types and infectious organisms was analyzed for associations with demographic and clinical data.
resultsAmong HIV-positive patients with infectious keratitis, herpes simplex virus (HSV) and varicella zoster virus (VZV) accounted for 71.4% of infections. The distribution of organisms differed significantly from a uniform distribution (
conclusionHIV-positive patients with keratitis are most likely to be colonized by HSV or VZV in infectious cases. HIV infection and ART usage are associated with chronic inflammation that may be related to dry eye disease. Racial and socioeconomic disparities continue to influence access to care in patients with HIV.
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