ArticleSaudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
Corneal biopsy as a primary diagnostic tool in microbial keratitis patients on poly-antimicrobials.
Article in Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo evaluate the role of corneal biopsy in nonhealing keratitis patients on multiple antimicrobials.
methodsIn a randomized, prospective, interventional study conducted at a tertiary eye center in India, 44 patients with infectious keratitis were recruited from February 2022 to October 2023. The cases that were on ≥2 topical antimicrobial drugs belonging to 2 different classes for ≥1 week with no signs of healing and corneal ulcer size of ≥4 mm were included. They were randomized into two groups: the corneal scraping group and the corneal biopsy group. The primary outcome measure was culture positivity rate, while the secondary outcome measures were smear positivity rate and complication rates in both groups.
resultsThe culture positivity rate of the corneal scraping group was 59.09% and the corneal biopsy group was 77.27% in cases of bacterial keratitis (
conclusionIn nonhealing keratitis with suspected fungal cause, corneal biopsy may be used as a primary diagnostic modality in a referral center.
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