Evidence map›Paper›PMID 42376295›Full record

ArticleFrontiers in bioengineering and biotechnology2026

Hemostatic efficacy of a novel Ca/P/S-based bone graft material and its preliminary clinical evidence in sternum closure procedures.

Jun-Neng Roan, Pao-Yen Lin, Jiin-Huey Chern Lin, Chen-Hsu Wang, Chun-Yu Liu, Chien-Ping Ju, Tai-Hua Yang

Abstract read
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In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jun-Neng RoanDivision of Cardiovascular Surgery, Department of Surgery, National Cheng-Kung University Hospital, College of Medicine, National Cheng-Kung University, Tainan, Taiwan.
Pao-Yen LinDivision of Cardiovascular Surgery, Department of Surgery, National Cheng-Kung University Hospital, College of Medicine, National Cheng-Kung University, Tainan, Taiwan.
Jiin-Huey Chern LinCenter for Biomaterials Research, National Cheng-Kung University, Tainan, Taiwan.
Chen-Hsu WangDepartment of Materials Science and Engineering, National Cheng-Kung University, Tainan, Taiwan.
Chun-Yu LiuDepartment of Materials Science and Engineering, National Cheng-Kung University, Tainan, Taiwan.
Chien-Ping JuCenter for Biomaterials Research, National Cheng-Kung University, Tainan, Taiwan.
Tai-Hua YangCenter for Biomaterials Research, National Cheng-Kung University, Tainan, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Median sternotomy is the standard approach for cardiac surgery. Still, it is often complicated by excessive marrow bleeding and impaired healing, particularly in frail patients, and conventional hemostatic agents can control bleeding but frequently compromise bone regeneration. We evaluated Ezechbone® Granule CBS-400, a fully synthetic Ca/P/S-based bone graft substitute, against commercially available calcium-based products to address this challenge.

Indexed as

bone regenerationCa-based bone substitutefibrin fiberhemostasisinflammation

Identifiers

PMID42376295
PMCPMC13310983

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.