ArticleFrontiers in molecular biosciences2026
Interaction of diosmetin, diosmin and diosmetin-7-O-glucoside with human erythrocytes, their model membrane, hemoglobin and redox-active metal ions.
Article in Frontiers in molecular biosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diosmin, a flavonoid with documented vascular-protective properties, together with the closely related compounds diosmetin and diosmetin-7-O-glucoside, has not previously been subjected to a systematic comparative biophysical characterization. In this study, we performed an integrated biophysical comparison of these three structurally related flavonoids to delineate how structural differences translate into distinct patterns of metal-ion coordination, membrane interaction and hemoglobin engagement, thereby providing a mechanistic context for their behavior in complex erythrocyte- and simplified hemoglobin-based redox systems. All three compounds exhibited low direct radical-scavenging activity in the DPPH• assay and showed differences in predicted lipophilicity and metal-ion interactions. Diosmetin, the most lipophilic derivative, selectively chelated Cu
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.