ReviewFrontiers in molecular neuroscience2026
Pathophysiology-driven neuroimaging: decoding brain injury in sepsis.
Review in Frontiers in molecular neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
7 authors.
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Abstract
Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction induced by sepsis, characterized by high mortality and frequent long-term cognitive impairment. Its pathogenesis involves multiple mechanisms, including endothelial activation, blood-brain barrier (BBB) disruption, neuroinflammation, and neurotransmitter imbalance, ultimately resulting in neuronal and glial injury. Recent advances in neuroimaging have provided new insights into the pathological features of SAE, while offering valuable tools for early diagnosis, prognostic stratification, and the identification of potential therapeutic targets. This Review summarizes recent advances in neuroimaging research in SAE, integrating clinical findings with pathophysiological and experimental evidence to delineate imaging phenotypes, elucidate underlying mechanisms, and highlight the translational potential of emerging imaging modalities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.