Evidence map›Paper›PMID 42376110›Full record

ArticleOpen veterinary journal2026

Subchronic comparative assessment of graded ferrous sulfate doses on biochemical, histological, and multiorgan micromorphological changes in wistar rats.

Ateeqah Ghayth Alzwawy, Abdelhafidh Khazri, Ahmed Kouki, Manel Ben Ali, Chayma Ben Fayala, Mossadok Ben Attia, Ezzeddine Mahmoudi, Mohsen Sakly, Riadh Marrouchi, Haifa Tounsi Kettiti

Abstract readComparative Study
PubMed Full text at PMC Publisher
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Article in Open veterinary journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Ateeqah Ghayth AlzwawyDepartment of Zoology, Faculty of Sciences, University of Ajdabia, Ajdabia, Libya.
Abdelhafidh KhazriLaboratory of Environment Biomonitoring LR01ES14, Faculty of Sciences of Bizerte, University of Carthage, Zarzouna, Tunisia.
Ahmed KoukiLaboratory of Environment Biomonitoring LR01ES14, Faculty of Sciences of Bizerte, University of Carthage, Zarzouna, Tunisia.
Manel Ben AliDepartment of Biology, College of Sciences, Taif University, Taif, Saudi Arabia.
Chayma Ben FayalaLaboratory of Human and Experimental Pathological Anatomy, Pasteur Institute of Tunis, Tunis El Manar University, PTunis-Belvédère, Tunisia.
Mossadok Ben AttiaLaboratory of Environment Biomonitoring LR01ES14, Faculty of Sciences of Bizerte, University of Carthage, Zarzouna, Tunisia.
Ezzeddine MahmoudiLaboratory of Environment Biomonitoring LR01ES14, Faculty of Sciences of Bizerte, University of Carthage, Zarzouna, Tunisia.
Mohsen SaklyLaboratory of Integrated Physiology LR17ES02, Faculty of Sciences of Bizerte, Carthage University, Jarzouna, Tunisia.
Riadh MarrouchiLaboratory of Venoms and Therapeutic Biomolecules, Pasteur Institute of Tunis, Tunis El Manar University, Tunis-Belvédère, Tunisia.
Haifa Tounsi KettitiLaboratory of Human and Experimental Pathological Anatomy, Pasteur Institute of Tunis, Tunis El Manar University, PTunis-Belvédère, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Iron is a necessary trace element in the human body. However, excessive concentration can promote the overproduction of reactive oxygen species, leading to oxidative stress and organ injury. Aim: This study aims to evaluate the biochemical and micromorphological changes that occur following exposure to graded doses of ferrous sulfate in a rat model. Methods: The treated groups (D1, D2, D3, and D4) were orally and daily treated with graded doses of ferrous sulfate (12.5 mg/kg [D1], 25 mg/kg [D2], 50 mg/kg [D3], and 100 mg/kg [D4]) for 6 weeks, whereas the control group received only saline solution (0.9% NaCl solution at 5 ml/kg body weight) during the same period. Results: Different doses of ferrous sulfate did not cause mortality. Weekly control of glucose levels in all rats revealed a remarkable interaction effect ( Conclusion: Excessive iron may cause oxidative damage to vital organs and alter blood glucose levels.

Indexed as

Ferrous CompoundsOxidative StressAnimalsBlood GlucoseDose-Response Relationship, DrugKidneyLiverMaleRatsRats, WistarBlood GlucoseFerrous Compoundsferrous sulfateGlycemiaHistopathologyIron overloadMultiple organ toxicityOxidative stress

Identifiers

PMID42376110
PMCPMC13314098

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