ReviewBrazilian journal of veterinary medicine2026
Oral drug delivery systems for companion animals: an integrative review of medicated treats, chewable tablets, and other pharmaceutical formulations.
Review in Brazilian journal of veterinary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Alopecia management from a comparative perspective: pharmacological and pharmaceutical insights in humans, dogs, and cats.Frontiers in veterinary science · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Administering oral medications to companion animals remains a major challenge in veterinary medicine, frequently leading to poor adherence and reduced therapeutic effectiveness. Medicated treats have emerged as a promising strategy to facilitate drug administration by combining active pharmaceutical ingredients with highly palatable food-based matrices. This integrative review critically synthesized the available scientific literature on oral drug delivery systems for dogs and cats, with emphasis on medicated treats, chewable formulations, therapeutic efficacy, safety, stability, and regulatory challenges. A structured search was conducted in PubMed, SciSpace, Consensus, and Google Scholar, using PRISMA-based procedures. After screening and eligibility assessment, 20 studies were included in the qualitative synthesis, including one additional eligible study incorporated after peer-review recommendation and assessed according to the same predefined criteria. The reviewed studies indicate that medicated treats and chewable oral formulations may improve treatment adherence, reduce administration-related stress, and maintain acceptable pharmacological performance when appropriate formulation parameters are met. Evidence also suggests that formulation-related factors, such as matrix composition and concomitant administration conditions, may influence bioavailability and product performance. Nevertheless, relevant challenges remain regarding dose uniformity, physicochemical stability, microbiological safety, and regulatory classification. Overall, medicated treats represent a promising alternative drug delivery strategy in veterinary therapeutics, particularly for chronic treatments in companion animals. Further studies are needed to optimize formulation parameters, evaluate long-term safety, and establish clearer regulatory frameworks for these hybrid pharmaceutical-nutritional products.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.