ArticleFrontiers in pediatrics2026
The association of chorioamnionitis with intraventricular hemorrhage and long-term outcome in very preterm neonates.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Objective: To evaluate the impact of chorioamnionitis on the incidence of intraventricular hemorrhage in preterm neonates and to assess its impact on neurodevelopmental outcomes at 24 months of age. Methods: We retrospectively reviewed the medical records of all neonates <32 weeks' gestational age born to mothers with and without histological chorioamnionitis. At 24 months of age, we evaluated long-term neurodevelopmental outcomes with the Gross Motor Function Classification System (GMFCS) and the Modified Checklist for Autism in Toddlers (M-CHAT). Results: Among 91 neonates with a mean gestational age of 29.1(±2.2) weeks, 54% (49 newborns) were exposed to chorioamnionitis during pregnancy. Neonates born to mothers with chorioamnionitis were of significantly lower gestational age (28.0 ± 2.3 vs. 30.2 ± 1.3 weeks, Conclusion: Very preterm neonates born to mothers with chorioamnionitis are at increased risk of severe intraventricular hemorrhage, retinopathy of prematurity, bronchopulmonary dysplasia, and an increased risk of abnormal M-CHAT at 24 months of age.
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