Evidence map›Paper›PMID 42375995›Full record

ArticleBJUI compass2026

State of the nation: Understanding the current NHS treatment pathway to identify opportunities to advance future care of patients with high-risk non-muscle invasive bladder cancer in the UK (SPAN-UK).

Jonathan Aning, James W F Catto, Rebecca Martin, Kathryn Chatterton, Paramananthan Mariappan, Edward Ottley, Joseph Hickey, Stephen McCormack, Simran Gill, Bernadett Szabados

Abstract read
In one paragraph

Article in BJUI compass, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jonathan AningBristol Urological Institute North Bristol NHS Trust Bristol UK.ORCID https://orcid.org/0000-0001-6189-4720
James W F CattoDivision of Clinical Medicine, School of Medicine and Population Health University of Sheffield Sheffield UK.
Rebecca MartinThe Royal Marsden NHS Foundation Trust London UK.ORCID https://orcid.org/0000-0001-6242-1327
Kathryn ChattertonGuy's and St Thomas' NHS Foundation Trust London UK.
Paramananthan MariappanEdinburgh Bladder Cancer Surgery (EBCS), Western General Hospital University of Edinburgh Edinburgh UK.
Edward OttleyReal World Evidence OPEN Health Communications LLP London UK.ORCID https://orcid.org/0009-0001-1942-4044
Joseph HickeyReal World Evidence OPEN Health Communications LLP London UK.
Stephen McCormackJ&J Innovative Medicine High Wycombe UK.
Simran GillJ&J Innovative Medicine High Wycombe UK.
Bernadett SzabadosUniversity College London Hospitals NHS Foundation Trust London UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: This study aimed to understand clinical pathways for patients with high-risk non-muscle-invasive bladder cancer (HR-NMIBC) from diagnosis to follow-up and to identify opportunities to improve care. Materials and Methods: A cross-sectional survey was conducted via structured online interviews with consented NHS healthcare professionals (HCPs) from the United Kingdom (UK) between June and September 2025. Topics surveyed included MDT structures/roles, diagnostic timelines, adjuvant treatment, radical cystectomy (RC) decision making, current bladder-sparing treatment and clinical trial access. Quantitative data were analysed descriptively. Qualitative responses were analysed thematically. Results: Seventy HCPs were included and reported that typically; 88.5% of patients achieve diagnosis within 6-8 weeks of referral, and 11.4% reported delays beyond 8 weeks. BCG maintenance duration and completion rates varied. Following BCG induction, a median (IQR) of 20.0% (5.0-32.5%) and 60.0% (40.0-70.0%) of patients completed ≥2 or ≤1 years of maintenance, respectively; 1.0% (1.0-2.0%) failed to complete induction. For BCG-unresponsive HR-NMIBC, HCPs reported that a mean ( Conclusion: Results reveal variability in real-world HR-NMIBC care within the NHS. Delays in diagnosis, inconsistent BCG maintenance duration, lack of evidence-based alternatives to BCG and a lack of bladder-sparing treatment and trial options in the BCG-unresponsive setting were identified. Findings highlight unmet needs in relation to MDT resourcing, diagnostic efficiency, trial access, QPI adherence and a national bladder cancer audit.

Indexed as

BCGbladder cancercross‐sectional surveyHR‐NMIBCnon‐muscle invasive bladder cancerQPIradical cystectomyreal‐worldtreatment pathway

Identifiers

PMID42375995
PMCPMC13310956

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.