Evidence map›Paper›PMID 42375982›Full record

ArticleOpen veterinary journal2026

Perioperative analgesia and clinical safety of dexketoprofen in dogs undergoing ovariohysterectomy.

Ismael Hernández-Avalos, Navid Ziaei-Darounkolaei, Nadia Crosignani-Outeda, Pedro Sánchez-Aparicio, Alejandra García-Peralta, Alejandro Casas-Alvarado, María Del Rosario Arvizu-Venegas, Agatha Elisa Miranda-Cortés

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Article in Open veterinary journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ismael Hernández-AvalosClinical Pharmacology and Veterinary Anesthesia, Biological Sciences Department, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México (UNAM), Cuautitlán, México.
Navid Ziaei-DarounkolaeiDepartment of Surgery and Radiology, Faculty of Veterinary Medicine, Bab.C., Islamic Azad University, Babol, Iran.
Nadia Crosignani-OutedaDepartment of Clinics and Veterinary Hospital, School of Veterinary, University of the Republic, Montevideo, Uruguay.
Pedro Sánchez-AparicioDepartment of Veterinary Pharmacology, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, México.
Alejandra García-PeraltaClinical Pharmacology and Veterinary Anesthesia, Biological Sciences Department, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México (UNAM), Cuautitlán, México.
Alejandro Casas-AlvaradoNeurophysiology of Pain, Behavior and Animal Welfare Assessment, DPAA, Universidad Autónoma Metropolitana (UAM), Mexico City, México.
María Del Rosario Arvizu-VenegasDepartment of Surgery, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México (UNAM), Cuautitlán, México.
Agatha Elisa Miranda-CortésPharmacology and Toxicology of Substances of Veterinary Interest, Biological Sciences Department, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México (UNAM), Cuautitlán, México.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Perioperative nociception and pain are among the most frequent signs observed following animal surgical procedures. Proper management of perioperative pain is essential for the well-being of animals and the stability of physiological, hemodynamic, biochemical, and behavioral parameters. Aim: This study aimed to evaluate the analgesic efficacy and clinical safety of dexketoprofen in dogs undergoing ovariohysterectomy (OVH) by assessing liver and kidney function-related serum and blood parameters. Methods: 30 healthy dogs of different breeds were randomly divided into two groups. G1 ( Results: G1 showed hemodynamic reactivity in systolic blood pressure to surgical manipulation of E Conclusion: Dexketoprofen offers effective pain relief with short-term (48 hours) clinical safety similar to that of meloxicam in dogs undergoing OVH, highlighting its potential as a dependable option for multimodal pain management during elective surgical procedures.

Indexed as

AnalgesiaAnti-Inflammatory Agents, Non-SteroidalHysterectomyKetoprofenOvariectomyPostoperative PainTromethamineAnimalsDogsFemaleAnti-Inflammatory Agents, Non-Steroidaldexketoprofen trometamolKetoprofenTromethamineAnalgesiaDexketoprofenDogsHepatic toxicityRenal toxicity

Identifiers

PMID42375982
PMCPMC13314117

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.