ArticleOpen veterinary journal2026
Biotransformation and detoxification enzyme (CYP1A2, CYP2E1, and GST) activities in vital organs of rats using liver extracts of
Article in Open veterinary journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Detoxification enzymes, including cytochrome P450 isoforms (CYP1A2 and CYP2E1) and glutathione-S-transferase (GST), play key roles in xenobiotic metabolism and organ protection. Although crocodile-derived bioactive compounds have gained biomedical interest, the Aim: To evaluate the effects of oral administration of Methods: Male Wistar rats ( Results: Crocodile liver extract produced dose-dependent and tissue-specific modulation of detoxification enzymes. Hepatic CYP1A2 showed a biphasic response, with catalytic efficiency increasing markedly at 400-800 mg/kg. Hepatic CYP2E1 activity increased toward 400 mg/kg before stabilizing. In the kidneys, CYP1A2, CYP2E1, and GST activities were consistently elevated, with GST showing the strongest induction; V Conclusion: Oral supplementation with
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