ArticleOpen veterinary journal2026
Assessment of
Article in Open veterinary journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Aim: This study aimed to isolate, purify, and characterize LPS from Salmonella spp. isolates, confirm the bacterial strains through molecular phylogenetic analysis, evaluate the immune responses induced by LPS in host models, and assess their potential as a candidate for vaccine development. Methods: We identified clinical isolates using biochemical and molecular (sequence-based) tools. LPS was extracted and purified using the hot phenol-water method. The molecular integrity of LPS and the presence of a ladder O-antigen were detected by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Experimental animals were immunized with LPS, and their immune responses were evaluated by estimating serum cytokine [TNF -α, Interleukin-6 (IL-6), Interleukin-1 beta (IL-1β), Interferon-gamma (IFN-γ)] levels, IgM and IgG antibody responses, and challenge protection rate. Descriptive statistics were performed, and Results: Sequence alignment and phylogenetic analyses confirmed that the isolates were Salmonella spp. with close genetic distances to the reference strains. SDS-PAGE indicated a crystal clear and smooth-type LPS profile with clear O-antigens. LPS immunization effectively provoked significant levels of tumor necrosis factor-alpha, IL-6, IL-1β, and IFN-γ ( Conclusion: The extracted LPS was predictably immunogenic, exhibiting robust innate and adaptive immune responses, and thus could be envisioned as a novel candidate for the development of Salmonella vaccines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.