ArticleCureus2026
Assessment of Oxidative Stress and Neuronal Damage Indicators After Parathyroidectomy in Patients With Primary Hyperparathyroidism.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
backgroundPrimary hyperparathyroidism (PHPT) is associated with neurological damage, which tends to improve after parathyroidectomy (PTX). Oxidative stress might play a role in these pathological changes. This study aimed to investigate oxidative stress and neuronal damage markers following PTX in patients with PHPT.
methodsThe study involved 36 patients with PHPT who underwent surgical treatment. Markers for oxidative stress, including serum total antioxidant status (TAS), total oxidative status (TOS), oxidative stress index (OSI), 7-ketocholesterol (7-KC) and cholestan-3β,5α,6β-triol (C-triol) as oxysterols and 8-iso-prostaglandin F2α (8-iso-PGF2α), were measured, along with neurofilament light chain (NfL) as a marker for neuronal damage. These markers were assessed before and six months after PTX.
resultsFollowing PTX, a significant reduction in OSI was observed (
conclusionsThese findings suggest oxidative stress is elevated in patients with PHPT and may contribute to neurological complications. Post surgery, oxidative stress levels decrease, as reflected by a significant reduction in OSI; whether this translates into better central nervous system outcomes warrants confirmation in future studies.
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