Evidence map›Paper›PMID 42375788›Full record

ArticleThe American journal of geriatric psychiatry. Open science, education, and practice2026

Association of Adverse Childhood Experiences and Cognitive Health in Older Adults: Rush Memory and Aging Project.

Jocelyn Jaen, Melissa Lamar, Brittney S Lange-Maia, Daisy T Noriega-Makarskyy, Liliana Gómez-Flores-Ramos, Martin Lajous, David A Bennett, Francine Grodstein

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In one paragraph

Article in The American journal of geriatric psychiatry. Open science, education, and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jocelyn JaenRush Alzheimer's Disease Center, Rush University Medical Center (JJ, ML, BSLM, DAB, FG), Chicago, IL; Department of Psychiatry and Behavioral Sciences, Rush University Medical Center (ML), Chicago, IL; Department of Family and Preventive Medicine, Rush University Medical Center (BSLM), Chicago, IL; Department of Psychology, USC Dornsife College of Letters, Arts, and Sciences (DTNM), Los Angeles, CA; SECIHTI - Center for Population Health Research, National Institute of Public Health (LGFR), Ciudad de México, Mexico; Center for Population Health Research, National Institute of Public Health (JJ, ML), Ciudad de México, Mexico; Department of Global Health and Population, Harvard T.H. Chan School of Public Health (ML), Boston, MA; Department of Neurological Sciences, Rush University Medical Center (DAB), Chicago, IL; and the Department of Internal Medicine, Rush University Medical Center (FG), Chicago, IL.
Melissa LamarRush Alzheimer's Disease Center, Rush University Medical Center (JJ, ML, BSLM, DAB, FG), Chicago, IL; Department of Psychiatry and Behavioral Sciences, Rush University Medical Center (ML), Chicago, IL; Department of Family and Preventive Medicine, Rush University Medical Center (BSLM), Chicago, IL; Department of Psychology, USC Dornsife College of Letters, Arts, and Sciences (DTNM), Los Angeles, CA; SECIHTI - Center for Population Health Research, National Institute of Public Health (LGFR), Ciudad de México, Mexico; Center for Population Health Research, National Institute of Public Health (JJ, ML), Ciudad de México, Mexico; Department of Global Health and Population, Harvard T.H. Chan School of Public Health (ML), Boston, MA; Department of Neurological Sciences, Rush University Medical Center (DAB), Chicago, IL; and the Department of Internal Medicine, Rush University Medical Center (FG), Chicago, IL.
Brittney S Lange-MaiaRush Alzheimer's Disease Center, Rush University Medical Center (JJ, ML, BSLM, DAB, FG), Chicago, IL; Department of Psychiatry and Behavioral Sciences, Rush University Medical Center (ML), Chicago, IL; Department of Family and Preventive Medicine, Rush University Medical Center (BSLM), Chicago, IL; Department of Psychology, USC Dornsife College of Letters, Arts, and Sciences (DTNM), Los Angeles, CA; SECIHTI - Center for Population Health Research, National Institute of Public Health (LGFR), Ciudad de México, Mexico; Center for Population Health Research, National Institute of Public Health (JJ, ML), Ciudad de México, Mexico; Department of Global Health and Population, Harvard T.H. Chan School of Public Health (ML), Boston, MA; Department of Neurological Sciences, Rush University Medical Center (DAB), Chicago, IL; and the Department of Internal Medicine, Rush University Medical Center (FG), Chicago, IL.
Daisy T Noriega-MakarskyyRush Alzheimer's Disease Center, Rush University Medical Center (JJ, ML, BSLM, DAB, FG), Chicago, IL; Department of Psychiatry and Behavioral Sciences, Rush University Medical Center (ML), Chicago, IL; Department of Family and Preventive Medicine, Rush University Medical Center (BSLM), Chicago, IL; Department of Psychology, USC Dornsife College of Letters, Arts, and Sciences (DTNM), Los Angeles, CA; SECIHTI - Center for Population Health Research, National Institute of Public Health (LGFR), Ciudad de México, Mexico; Center for Population Health Research, National Institute of Public Health (JJ, ML), Ciudad de México, Mexico; Department of Global Health and Population, Harvard T.H. Chan School of Public Health (ML), Boston, MA; Department of Neurological Sciences, Rush University Medical Center (DAB), Chicago, IL; and the Department of Internal Medicine, Rush University Medical Center (FG), Chicago, IL.
Liliana Gómez-Flores-RamosRush Alzheimer's Disease Center, Rush University Medical Center (JJ, ML, BSLM, DAB, FG), Chicago, IL; Department of Psychiatry and Behavioral Sciences, Rush University Medical Center (ML), Chicago, IL; Department of Family and Preventive Medicine, Rush University Medical Center (BSLM), Chicago, IL; Department of Psychology, USC Dornsife College of Letters, Arts, and Sciences (DTNM), Los Angeles, CA; SECIHTI - Center for Population Health Research, National Institute of Public Health (LGFR), Ciudad de México, Mexico; Center for Population Health Research, National Institute of Public Health (JJ, ML), Ciudad de México, Mexico; Department of Global Health and Population, Harvard T.H. Chan School of Public Health (ML), Boston, MA; Department of Neurological Sciences, Rush University Medical Center (DAB), Chicago, IL; and the Department of Internal Medicine, Rush University Medical Center (FG), Chicago, IL.
Martin LajousRush Alzheimer's Disease Center, Rush University Medical Center (JJ, ML, BSLM, DAB, FG), Chicago, IL; Department of Psychiatry and Behavioral Sciences, Rush University Medical Center (ML), Chicago, IL; Department of Family and Preventive Medicine, Rush University Medical Center (BSLM), Chicago, IL; Department of Psychology, USC Dornsife College of Letters, Arts, and Sciences (DTNM), Los Angeles, CA; SECIHTI - Center for Population Health Research, National Institute of Public Health (LGFR), Ciudad de México, Mexico; Center for Population Health Research, National Institute of Public Health (JJ, ML), Ciudad de México, Mexico; Department of Global Health and Population, Harvard T.H. Chan School of Public Health (ML), Boston, MA; Department of Neurological Sciences, Rush University Medical Center (DAB), Chicago, IL; and the Department of Internal Medicine, Rush University Medical Center (FG), Chicago, IL.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center (JJ, ML, BSLM, DAB, FG), Chicago, IL; Department of Psychiatry and Behavioral Sciences, Rush University Medical Center (ML), Chicago, IL; Department of Family and Preventive Medicine, Rush University Medical Center (BSLM), Chicago, IL; Department of Psychology, USC Dornsife College of Letters, Arts, and Sciences (DTNM), Los Angeles, CA; SECIHTI - Center for Population Health Research, National Institute of Public Health (LGFR), Ciudad de México, Mexico; Center for Population Health Research, National Institute of Public Health (JJ, ML), Ciudad de México, Mexico; Department of Global Health and Population, Harvard T.H. Chan School of Public Health (ML), Boston, MA; Department of Neurological Sciences, Rush University Medical Center (DAB), Chicago, IL; and the Department of Internal Medicine, Rush University Medical Center (FG), Chicago, IL.
Francine GrodsteinRush Alzheimer's Disease Center, Rush University Medical Center (JJ, ML, BSLM, DAB, FG), Chicago, IL; Department of Psychiatry and Behavioral Sciences, Rush University Medical Center (ML), Chicago, IL; Department of Family and Preventive Medicine, Rush University Medical Center (BSLM), Chicago, IL; Department of Psychology, USC Dornsife College of Letters, Arts, and Sciences (DTNM), Los Angeles, CA; SECIHTI - Center for Population Health Research, National Institute of Public Health (LGFR), Ciudad de México, Mexico; Center for Population Health Research, National Institute of Public Health (JJ, ML), Ciudad de México, Mexico; Department of Global Health and Population, Harvard T.H. Chan School of Public Health (ML), Boston, MA; Department of Neurological Sciences, Rush University Medical Center (DAB), Chicago, IL; and the Department of Internal Medicine, Rush University Medical Center (FG), Chicago, IL.

Funding

EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
NIA NIH HHS R01 AG017917
6 · The paper itself

Abstract

Objective: To examine the association between adverse childhood experiences (ACEs) and cognitive function and decline in older adults. Design: Analysis of baseline cognitive and annual rates of cognitive decline in participants from the Rush Memory and Aging Project (MAP). Setting: MAP is an ongoing cohort of older adults initiated in 1997. Participants: 1,869 participants without dementia at baseline. Measurements: ACEs were assessed using a 16-item questionnaire covering emotional neglect, financial need, parental intimidation, parental violence, and family turmoil. Cognitive function was evaluated annually using 19 neuropsychologic tests across five domains. Linear mixed-effects models estimated associations of ACEs with baseline global cognition and cognitive decline. Results: At baseline, participants had a mean age of 80 years and 15 years of education; 26% were male, and 92% were non-Latino White. The average total ACE score was 8.3 points (SD 7.6) of a possible 58 points; the mean follow-up was 7.6 years (SD 4.9). Total ACE score was not associated with baseline global cognition or with the annual rate of global cognitive decline. However, each increment of parental violence (mean difference = -0.032 standard units, p = 0.004), family turmoil (mean difference = -0.027, p = 0.007), and financial need (mean difference = -0.024, p = 0.01) was associated with lower baseline global cognition. Emotional neglect was associated with a steeper, annual rate of global cognitive decline (mean difference = -0.0014, p = 0.027). Conclusion: The total ACE score was not associated with cognitive health in later life. However, specific ACE dimensions, including parental violence, family turmoil, and financial need, may be related to baseline cognitive function in older persons.

Indexed as

Adverse childhood experiencesagingchildhood adversitycognition

Identifiers

PMID42375788
PMCPMC13313590

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.