SynthesisFrontiers in nutrition2026
Effects of nutritional supplementation combined with exercise on BMI and lipid profiles in individuals with overweight or obesity: a systematic review and meta-analysis.
Synthesis in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Background: This study systematically evaluated the effects of nutritional supplementation combined with exercise on BMI and lipid profiles in individuals with overweight or obesity. Methods: A systematic search was conducted in PubMed, Embase, Web of Science, and the Cochrane Library databases from their inception to January 10, 2026, to identify randomized controlled trials (RCTs) comparing "nutritional supplementation combined with exercise" with "placebo." The primary outcome measure was BMI; secondary outcomes included total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). Weight-adjusted mean differences (WMD) and 95% confidence intervals (CI) were calculated using a random-effects model. Data analysis was performed using Stata 15. Study reporting followed the PRISMA statement, and the risk of bias of included randomized controlled trials was assessed using the Cochrane RoB 2.0 tool. Results: Twelve RCTs involving 315 participants (161 in the intervention group and 154 in the control group) were included. Compared with placebo/control conditions, combined exercise and supplement-based interventions significantly reduced BMI (WMD = -1.72, 95% CI: -2.61 to -0.83; Conclusion: Nutritional supplementation combined with exercise may be associated with improvements in BMI and lipid profiles in individuals with overweight or obesity. However, because the included studies varied in supplement type, exercise protocol, intervention duration, and participant characteristics, the findings should be interpreted cautiously. Larger, well-designed randomized trials with standardized intervention protocols and longer follow-up are needed to confirm these effects.
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