ReviewBiochemistry and biophysics reports2026
The IL-33/ST2 pathway to modulate the inflammatory microenvironment: A new therapeutic target in chronic obstructive pulmonary disease.
Review in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Inflammation and Immune Dysregulation Across Respiratory Diseases: From Cellular Mechanisms to Therapeutic Targets.Journal of inflammation research · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The IL-33/ST2 pathway is critically implicated in the pathogenesis and progression of chronic obstructive pulmonary disease (COPD), orchestrating a complex interplay of oxidative stress, immunity, inflammation, and pulmonary injury. Clinical evidence shows that the expression levels of IL-33 and ST2 are significantly elevated in patients with COPD, which correlates strongly with disease severity, increased frequency of acute exacerbations, and negative clinical outcomes. Therapeutic strategies targeting the IL-33/ST2 pathway, including anti-IL-33 monoclonal antibodies and ST2 inhibitors, have demonstrated considerable potential in preclinical studies. These approaches have shown efficacy in mitigating inflammatory responses, enhancing lung function, and reducing the risk of acute exacerbations. Notably, the precise regulatory mechanisms of the IL-33/ST2 pathway in COPD and its crosstalk with inflammation remain incompletely understood and warrant further investigation. This review mainly elaborates the molecular biological characteristics and mechanism of IL-33/ST2, summarizes the function of IL-33/ST2 in COPD development and treatment, illustrates the application of IL-33/ST2 in patient's immune-inflammatory regulation and drug discovery, and discusses the prospects of targeting IL-33/ST2.
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Registered trials
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