Evidence map›Paper›PMID 42375680›Full record

ArticleBiochemistry and biophysics reports2026

DCAF7 enhances atherosclerosis in vascular endothelial cells by promoting SLC40A1 transcription through facilitating TNF-mediated NF-κB function.

Sien Guo, Peng Yan, Gengchen Niu, Biqi Li, Ni Wu, Qisen Yao, Shengyuan Wang, Chongyuan Hu, Yisheng Zheng, Yihe Yan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sien GuoDepartment of Vascular Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.
Peng YanDepartment of Vascular Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.
Gengchen NiuWarwick Medical School, University of Warwick, Coventry, CV4 7AL, United Kingdom.
Biqi LiDepartment of Pathology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, China.
Ni WuMedical Simulation Center, 15878170583 Teaching Department, The Peoples Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, 530021, China.
Qisen YaoDepartment of Hepatopancreatobiliary & Vascular Surgery, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, China.
Shengyuan WangDepartment of Vascular Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.
Chongyuan HuDepartment of Hepatopancreatobiliary & Vascular Surgery, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, China.
Yisheng ZhengDepartment of Hepatopancreatobiliary & Vascular Surgery, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, China.
Yihe YanDepartment of Hepatopancreatobiliary & Vascular Surgery, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, China.
Huafu LiImperial College London, Sir Alexander Fleming Building, South Kensington Campus, London, United Kingdom.
Chunming WangDepartment of Hepatopancreatobiliary & Vascular Surgery, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis (AS) poses a significant risk to human health. Our study, through the analysis of publicly available datasets, discovered that apoptosis plays a crucial role in the development of atherosclerosis. Additionally, we found that the iron apoptosis factor SLC40A1 is greatly increased, while the up-regulation of DCAF7 may be a significant contributing element to this impact. Therefore, we conducted tests both in vivo and in vitro to show that DCAF7 has the ability to influence the expression of SLC40A1 by impacting TNF and controlling the function of NF-κB, resulting in apoptosis. Following the creation of ApoE-/- mice, we suppressed the activity of DCAF7 and observed a substantial reduction in the advancement of carotid atherosclerosis and apoptosis in these animals. This suggests that DCAF7 plays a crucial role in the development of carotid atherosclerosis. Targeting DCAF7 has the potential to halt the progression of atherosclerosis.

Indexed as

ApoptosisCell death

Identifiers

PMID42375680
PMCPMC13311996

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.