ArticleInternational journal of dentistry2026
Design of a Novel Peptide-Based Vaccine Targeting
Article in International journal of dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Design of a Novel Peptide-Based Vaccine TargetingInternational journal of dentistry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Dental caries is a widespread oral health issue affecting both children and adults. Methods: The SpaP protein sequence was retrieved from UniProtKB. Adjuvants, a TLR4 agonist from Results: Six MHC-I, six MHC-II, and six BCEs were indicated from SpaP, for a total of 18 epitopes selected for vaccine design. Some of these have been experimentally validated according to IEDB. This vaccine indicated potential for favorable biochemical properties, including high stability, solubility, and antigenicity. Molecular docking predicted strong vaccine-TLR4 binding affinity, with a Gibbs free energy of binding of -315.77 kcal/mol. Normal mode analysis (NMA) further suggested the stability of the vaccine-TLR4 complex and showed minimal structural changes. This study presents a novel approach to the design of SpaP-targeted vaccines. Conclusion: This computationally designed MEV represents a promising candidate for experimental validation and offers a cost-effective, rational framework for developing next-generation dental caries vaccines with enhanced immunogenicity and broader protective coverage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.