ArticleFrontiers in pharmacology2026
Water intake during drinking does not alleviate hangover symptoms.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Hangovers can impair the ability to drive a car or work in industrial settings, in addition to causing unpleasant symptoms such as headaches and fatigue. As for reducing hangover symptoms, the effect of consuming water between drinks, often referred to as a "chaser," has been empirically recognized; however, this effect has not been verified to date. The purpose of this study was to clarify whether intermittent drinking of water during alcohol consumption affects the ethanol and acetaldehyde kinetics in the body and whether it alleviates hangover symptoms with the psychomotor function test and subjective symptoms on the following day. Methods: Thirteen healthy Japanese adult males with wild-type aldehyde dehydrogenase (ALDH)2 ( Results: No differences were observed between the two groups in the kinetics of exhaled ethanol and acetaldehyde. The DSST scores were similar between them. The VAS assessed subjective symptoms of facial flushing, headache, nausea, concentration, sleepiness, and mood elevation, and no differences were found between the two groups. Conclusion: The intermittent addition of drinking water during ethanol consumption did not significantly alter ethanol disposition or pharmacodynamic parameters, suggesting it did not affect hangover symptoms.
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