Evidence map›Paper›PMID 42375614›Full record

ArticleFrontiers in pharmacology2026

Soyeom-Jetong mixture attenuates NLRP3 inflammasome-mediated inflammation.

Qianying Ye, Sojung Lee, Yeon-Cheol Park, Myung-Seo Kim, Wonnam Kim, Jong-Sik Jin, Dong-Keun Kim, Seoyeon Jang, Sumin Lee, Nahyun Lee and 11 more

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Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

21 authors.

Qianying Ye *Department of Biomedical Science and Technology, Kyung Hee University, Seoul, Republic of Korea.
Sojung Lee *Department of Microbiology, Ajou University School of Medicine, Suwon, Republic of Korea.
Yeon-Cheol Park *Department of Acupuncture and Moxibustion, Joint and Spine Center, Kyung Hee University College of Korean Medicine, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea.
Myung-Seo KimDepartment of Orthopaedic Surgery, Shoulder and Elbow Clinic, Kyung Hee University School of Medicine, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea.
Wonnam KimDivision of Pharmacology, School of Korean Medicine, Pusan National University, Yangsan, Republic of Korea.
Jong-Sik JinDepartment of Oriental Medicine Resources and LED Agri-bio Fusion Technology Research Center, Jeonbuk National University, Iksan, Republic of Korea.
Dong-Keun KimCollege of Pharmacy, Jeonbuk National University, Jeonju, Republic of Korea.
Seoyeon JangDepartment of Biomedical Science and Technology, Kyung Hee University, Seoul, Republic of Korea.
Sumin LeeDepartment of Microbiology, Ajou University School of Medicine, Suwon, Republic of Korea.
Nahyun LeeClinical Research Institute, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
Seongjong LeeDepartment of Microbiology, Ajou University School of Medicine, Suwon, Republic of Korea.
Byung-Kwan SeoDepartment of Acupuncture and Moxibustion, Joint and Spine Center, Kyung Hee University College of Korean Medicine, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea.
Man S KimClinical Research Institute, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
Yeonhak KimEast-West Bone and Joint Disease Research Institute, Kyung Hee University, Seoul, Republic of Korea.
Duckgun AnDepartment of Clinical Practice, Jahwang Korean Medicine Hospital, Gyeonggi-do, Republic of Korea.
Sangsu SeoDepartment of Research and Development, KSCP, Gyeonggi-do, Republic of Korea.
Donggyu LeeDepartment of Academic Research, Korea Society of Clinical Pharmacopuncture, Seoul, Republic of Korea.
Hyungyu KimDepartment of Academic Research, Korea Society of Clinical Pharmacopuncture, Seoul, Republic of Korea.
Yong Hwan ParkDepartment of Microbiology, Ajou University School of Medicine, Suwon, Republic of Korea.
Yoonsung LeeDepartment of Biomedical Science and Technology, Kyung Hee University, Seoul, Republic of Korea.
Yong-Hyeon BaekDepartment of Acupuncture and Moxibustion, Joint and Spine Center, Kyung Hee University College of Korean Medicine, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSoyeom-Jetong (SJ) is a traditional East Asian polyherbal formulation composed of

methodsInflammation was induced in zebrafish embryos via LPS exposure and tail amputation. The anti-inflammatory effects of SJ were assessed through Sudan Black B staining and whole-mount

resultsSJ significantly reduced neutrophil accumulation in the caudal hematopoietic tissue of LPS-exposed zebrafish and the injury site of zebrafish embryos with amputated tails. It also modulated inflammatory gene expression, including NLRP3 and proinflammatory cytokines.

conclusionSJ exhibits anti-inflammatory activity by modulating neutrophil inflammation and suppressing NLRP3 inflammasome activation

Indexed as

anti-inflammatoryinflammasomeNLRP3Soyeom-Jetongzebrafish

Identifiers

PMID42375614
PMCPMC13313603

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