ArticleFood science & nutrition2026
Deciphering the Therapeutic and Preventive Potential of Dietary Tannins in Osteosarcoma: A Multi-Omics Approach Targeting TGFA and Immune Microenvironment Remodeling.
Article in Food science & nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
Malignant tumors, including osteosarcoma (OS), are major non-communicable chronic diseases driven by systemic inflammation and oxidative stress. While dietary tannins possess known antioxidant and anticancer properties, their precise regulatory mechanisms and therapeutic targets in OS remain largely unexplored. This study integrated multi-omics datasets to systematically investigate the potential of dietary tannins in OS, utilizing a machine-learning framework based on 10 algorithms to construct a tannin-related risk (TRR) score. The TRR model demonstrated favorable prognostic performance in retrospective cohorts, with high-TRR patients exhibiting poorer survival, enrichment of extracellular matrix remodeling pathways, and reduced CD8
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