Evidence map›Paper›PMID 42375540›Full record

ArticleiScience2026

A digital microfluidic platform for cell-based non-invasive testing.

Dylan Siriwardena, Michael D M Dryden, M Dean Chamberlain, Chloe Taylor, Louise Dupoiron, Shriya Gulati, Farhana Abbas, Julian Lamanna, David Chitayat, Aaron R Wheeler and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dylan SiriwardenaDepartment of Chemistry, University of Toronto, Toronto, ON, Canada.
Michael D M DrydenDepartment of Chemistry, University of Toronto, Toronto, ON, Canada.
M Dean ChamberlainDepartment of Chemistry, University of Toronto, Toronto, ON, Canada.
Chloe TaylorDepartment of Chemistry, University of Toronto, Toronto, ON, Canada.
Louise DupoironDepartment of Chemistry, University of Toronto, Toronto, ON, Canada.
Shriya GulatiDepartment of Chemistry, University of Toronto, Toronto, ON, Canada.
Farhana AbbasDepartment of Chemistry, University of Toronto, Toronto, ON, Canada.
Julian LamannaDepartment of Chemistry, University of Toronto, Toronto, ON, Canada.
David ChitayatDepartment of Obstetrics & Gynaecology, Sinai Health System, Toronto, ON, Canada.
Aaron R WheelerDepartment of Chemistry, University of Toronto, Toronto, ON, Canada.
Elena GreenfeldDivision of Diagnostic Medical Genetics, Sinai Health System, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gold-standard prenatal genetic diagnostics rely on invasive sampling procedures, which carry a small risk of miscarriage and do not yield results until after 14 weeks of gestation. Cervical mucosa is a promising cellular source for intact fetal cells but is limited by the paucity of fetal cells. We apply digital microfluidic isolation of single cells for omics (DISCO) to collect fetal cells from cervical mucosa for prenatal genetic diagnostics. Using gold standard markers, we collected putative fetal cells from transcervical swabs but found the material was predominantly of maternal origin. By integrating placental and transcervical swab transcriptomes, we identified a population of putative fetal cells characterized by 147 marker genes in common with fetal placental tissue. DISCO collections of prospective fetal cells contained identifiable fetal and maternal DNA. Thus, our DISCO system enabled the identification of fetal cell markers, collection of putative fetal cells, and analysis of fetal DNA.

Indexed as

biological sciencesbiological sciences research methodologiesdevelopmental geneticsdiagnostic procedurefluidicsomics

Identifiers

PMID42375540
PMCPMC13311143

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.