Evidence map›Paper›PMID 42375534›Full record

ArticleiScience2026

Mitochondrial-generated G-quadruplex-forming lncRNAs regulate heme homeostasis.

Vinodh J Sahayasheela, Ryohei Noizumi, Manendra B Lankadasari, Takumi Terada, Mitsuharu Ooga, Atharv Kulkarni, Shinjiro Suzuki, Takuya Hidaka, Li Cai, Ganesh N Pandian and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Vinodh J SahayasheelaDepartment of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-Ku, Kyoto 606-8502, Japan.
Ryohei NoizumiDepartment of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-Ku, Kyoto 606-8502, Japan.
Manendra B LankadasariThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Takumi TeradaDepartment of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-Ku, Kyoto 606-8502, Japan.
Mitsuharu OogaDepartment of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-Ku, Kyoto 606-8502, Japan.
Atharv KulkarniDepartment of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854, USA.
Shinjiro SuzukiDepartment of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-Ku, Kyoto 606-8502, Japan.
Takuya HidakaDepartment of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-Ku, Kyoto 606-8502, Japan.
Li CaiDepartment of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854, USA.
Ganesh N PandianInstitute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Yoshida-Uninomiyacho, Sakyo-Ku, Kyoto 606-8501, Japan.
Toshikazu BandoDepartment of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-Ku, Kyoto 606-8502, Japan.
Amit R ReddiSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA.
Hiroshi SugiyamaDepartment of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-Ku, Kyoto 606-8502, Japan.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Heme is an essential but potentially toxic prosthetic group synthesized in mitochondria. Maintaining mitochondrial heme homeostasis requires precise regulation of labile heme availability. Here, we show that mitochondria-generated long non-coding RNAs (mt-lncRNAs) are enriched in G-quadruplex-forming sequences and that these RNA G-quadruplex (rG4) structures bind and buffer heme. Using G4-specific pull-down and bio-orthogonal imaging, we demonstrate rG4 formation in mt-lncRNAs inside cells and show that mt-lncRNA rG4s bind hemin

Indexed as

biochemistrybiophysicsmolecular biology

Identifiers

PMID42375534
PMCPMC13311188

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.