ArticleOpen veterinary journal2026
Effects of Oral Nanocurcumin on Uterine Caspase-3 and IL-10 Expression in Noise-Stressed Pregnant Mice.
Article in Open veterinary journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Exposure to environmental noise during pregnancy has been linked to the disruption of immune and apoptotic balance in uterine tissues. Caspase-3 (Casp-3) and interleukin-10 (IL-10) are key apoptosis and anti-inflammatory signaling biomarkers, respectively. Nanocurcumin has shown promise as an antioxidant and immunomodulator. Aim: This study aimed to evaluate the effects of oral nanocurcumin on Casp-3 and IL-10 expression in gestational noise-exposed pregnant mice. Methods: Twenty-five pregnant BALB/c mice were divided into five groups: negative control (K-), positive control with noise (K+), and three treatment groups exposed to noise and given nanocurcumin at 14 (P1), 21 (P2), and 24.5 mg/kg body weight (BW) (P3). Oral treatments were given from gestational day (GD) 6-18. Uterine tissues were harvested for immunohistochemical analysis. Data were analyzed using analysis of variance, Tukey's HSD, and linear regression ( Results: Noise exposure increased Casp-3 and reduced IL-10 expression ( Conclusion: Oral nanocurcumin effectively reduced uterine apoptotic signaling and improved anti-inflammatory responses in pregnancies with noise stress, supporting its potential role as a non-hormonal therapeutic in reproductive stress conditions. This study also aligns with the Sustainable Development Goal (SDG) 3: Good Health and Well-being, particularly in advancing maternal health through nutraceutical interventions during pregnancy under environmental stress.
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