ArticleOpen veterinary journal2026
Effect of desmopressin on buccal mucosal bleeding time in healthy dogs.
Article in Open veterinary journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Desmopressin acetate (DDAVP) is used as a hemostatic adjunct because it can improve primary hemostasis and increase Factor VIII- and von Willebrand factor-related variables. However, its effects in dogs under general anesthesia are not well defined. Aim: This study aimed to evaluate the effect of DDAVP on buccal mucosal bleeding time (BMBT) in anesthetized healthy dogs and to assess concurrent changes in plasma FVIII antigen (FVIII:Ag). Methods: Twenty-seven healthy Beagle dogs were randomly assigned to receive intravenous saline (control; Results: At 30 minutes after administration, the BMBT values were 128.2 (92.1-157.7) seconds in the control group, 105.2 (72.4-122.0) seconds in the 0.6 µg/kg group, 74.1 (58.6-101.8) seconds in the 1.2 µg/kg group, and 47.2 (44.4-76.1) seconds in the 1.8 µg/kg group.BMBT was significantly shorter in the 1.2 and 1.8 µg/kg groups than in the controls, and in the 1.8 µg/kg group than in the 0.6 µg/kg group ( Conclusion: DDAVP dose-dependently shortened BMBT and increased FVIII:Ag in 60 minutes in healthy anesthetized dogs. These findings provide preliminary data and support further investigation of DDAVP in patients undergoing surgery.
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