ArticleOpen veterinary journal2026
Effects of the methanolic extract of
Article in Open veterinary journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
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Abstract
Background: During innate immunity, peritoneal macrophages (PMs) orchestrate early nitro-oxidative and chemokine responses, and their polarization is influenced by mouse strain-dependent metabolic programs. Aim: To investigate the effects of a methanolic extract of Methods: Lipopolysaccharide (LPS)-elicited PMs were obtained from female BALB/c and C57BL/6 mice. The cytotoxicity and half-maximal inhibitory concentrations (IC50) of MET.s were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay. Nitric oxide (NO) production was quantified using the Griess reaction. Gene expression of Results: MET.s did not reduce mitochondrial activity in either strain; IC50 values were 4.76 µg/ml for BALB/c and 81.92 µg/ml for C57BL/6 PMs. BALB/c PMs exhibited a modest but significant increase in NO at 50 µg/ml, whereas C57BL/6 PMs exhibited decreased NO at the same concentration, inverting the expected strain pattern. In BALB/c PMs, MET.s alone or in combination with LPS or IL-4 favored Conclusion: The MET.s exerts non-cytotoxic, strain-dependent immunomodulatory effects on PMs, reshaping nitro-oxidative output and chemokine gene expression to favor a context-dependent balance between activation and regulation. These findings support its potential as a natural immunomodulator and justify further mechanistic and
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