ArticleFrontiers in aging2026
Effects of Kiperin Elixea, a multicomponent antioxidant supplement, on redox homeostasis and longevity-associated gene expression in human epithelial cell models.
Article in Frontiers in aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Aging is characterized by declining NAD Methods: We evaluated the molecular and functional effects of Elixea, an NMN (nicotinamide mononucleotide)-based formulation containing NAD Results: Elixea maintained normal cell viability and migration dynamics, supporting the preservation of basal epithelial function. In hTERT-HME1 cells, treatment significantly improved redox homeostasis, as evidenced by increased TAS and reduced TOS levels. Gene expression analysis revealed significant upregulation of Discussion: Collectively, these findings suggest that Elixea modulates conserved longevity-associated pathways in a cell type-dependent manner, promoting cellular resilience without evidence of cytotoxicity or overt stress-associated responses. This study provides mechanistic evidence supporting the geroprotective potential of multi-component interventions targeting redox and metabolic networks in epithelial systems.
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