ArticleFrontiers in immunology2026
Baseline neutrophil-to-lymphocyte ratio combined with SLEDAI predicts lupus low disease activity state at 1 year: a cohort study.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Neutrophil-Dominant Inflammatory Responses and Inflammation-Coagulation Burden After Extremity Acute Compartment Syndrome: A Retrospective Multi-Cohort Study.Journal of inflammation research · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease in which treat-to-target management increasingly emphasizes attainment of Lupus Low Disease Activity State (LLDAS). Complete blood count (CBC)-derived inflammatory indices are inexpensive and readily available markers, but their value for predicting subsequent LLDAS remains unclear. Methods: This retrospective cohort study included 165 hospitalized patients with SLE at Peking University International Hospital between 2022 and 2024 who had baseline CBC data and completed 1-year follow-up. Baseline neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI) were calculated from routine hematologic parameters. The primary outcome was LLDAS achievement at 1 year according to Asia Pacific Lupus Collaboration criteria. Univariable and multivariable logistic regression analyses were performed. Multivariable models adjusted for baseline SLEDAI-2K, age, sex, immunosuppressant use, and prednisone dose. Receiver operating characteristic (ROC) analysis, bootstrap internal validation, calibration, and decision curve analysis (DCA) were also conducted. Results: Compared with non-LLDAS patients, those who achieved LLDAS had lower baseline SLEDAI-2K, lower prevalence of renal involvement, lower neutrophil counts, higher hemoglobin levels, and lower baseline NLR, PLR, SII, and SIRI. In univariable analysis, higher baseline NLR (OR 0.69, 95% CI 0.57-0.83, Conclusion: Baseline CBC-derived inflammatory indices, particularly NLR, were associated with 1-year LLDAS attainment in SLE. NLR, combined with SLEDAI-2K, may provide a practical, low-cost adjunct for early risk stratification in treat-to-target-oriented SLE management.
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