Evidence map›Paper›PMID 42375340›Full record

ArticleFrontiers in immunology2026

The Ste20 kinase TAOK3 restrains Rac-driven cytoskeletal-mitochondrial coupling to preserve naive CD8

Sahine Lameire, Lana Vandersarren, Andrew Brown, Philippe Pouliot, Sophie Janssens, Stijn Vanhee, Hamida Hammad, Bart N Lambrecht

Abstract read
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In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sahine LameireLaboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.
Lana VandersarrenLaboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.
Andrew BrownLaboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.
Philippe PouliotLaboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.
Sophie JanssensDepartment of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.
Stijn VanheeLaboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.
Hamida HammadLaboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.
Bart N LambrechtLaboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytoskeletal remodelling is central to naive T cell fitness, organizing receptor-proximal signaling and mechanotransduction during TCR engagement. However, how cytoskeletal dynamics are coordinated with TCR signaling to preserve naive T cell fitness remains incompletely defined. Here, we identify the

Indexed as

CD8-Positive T-LymphocytesCytoskeletonLymphocyte ActivationMitochondriaProtein Serine-Threonine Kinasesrac GTP-Binding ProteinsAnimalsGuanine Nucleotide Exchange FactorsHippo KinasesHomeostasisMiceMice, Inbred C57BLMice, KnockoutReceptors, Antigen, T-CellSignal TransductionDock8 protein, mouseGuanine Nucleotide Exchange FactorsHippo KinasesProtein Serine-Threonine Kinasesrac GTP-Binding ProteinsReceptors, Antigen, T-Cellcytoskeletonnaive CD8+ T cellsnaive T cell homeostasisRac (Rac GTPase)TCR - T cell receptor

Identifiers

PMID42375340
PMCPMC13311001

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.