ReviewFrontiers in endocrinology2026
Laparoscopic sleeve gastrectomy in adults with Prader-Willi syndrome and super-morbid obesity: a case report and literature review.
Review in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Objective: This study aimed to systematically assess perioperative clinical safety, medium-term weight loss outcomes, multidisciplinary management challenges, and the clinical applicability of laparoscopic sleeve gastrectomy (LSG) in adults with Prader-Willi syndrome (PWS) and super-morbid obesity (body mass index [BMI] ≥ 50 kg/m²), with the objective of identifying appropriate candidates for surgical intervention and establishing standardized perioperative management strategies. Case report: A 24-year-old male with PWS and super-morbid obesity (BMI: 64.44 kg/m²) underwent LSG following comprehensive multidisciplinary team (MDT) evaluation. Short-term postoperative recovery was uneventful; however, long-term weight reduction outcomes and the risk of postoperative complications remained uncertain. A review of the literature suggested that although LSG was associated with modest weight reduction in patients with PWS, significant postoperative management challenges remained, including behavioral issues, nutritional monitoring requirements, and the need for long-term multidisciplinary support. Conclusion: LSG should not be considered a first-line intervention for patients with PWS. Surgical intervention should be restricted to carefully selected patients following comprehensive MDT evaluation. Optimized perioperative behavioral management, together with emerging pharmacological therapies and non-invasive ventilatory support, may expand surgical eligibility within this patient population.
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