Evidence map›Paper›PMID 42375320›Full record

ArticleFrontiers in endocrinology2026

α-cell SLC38A5 supports amino acid-induced α-cell proliferation and glucagon secretion.

Katelyn Sellick, Anna Marie R Schornack, Tyler J Rodgers, Fedora O Ogodo, Mounika Aramandla, Jade E Stanley, Walter Siv, Matthew Shou, Nitin C Shankar, Soham S Saraf and 2 more

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In one paragraph

Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Katelyn Sellick *Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, TN, United States.
Anna Marie R Schornack *Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, United States.
Tyler J RodgersDivision of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, TN, United States.
Fedora O OgodoDivision of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, TN, United States.
Mounika AramandlaDivision of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, TN, United States.
Jade E StanleyDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, United States.
Walter SivDivision of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, TN, United States.
Matthew ShouDivision of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, TN, United States.
Nitin C ShankarDivision of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, TN, United States.
Soham S SarafDivision of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, TN, United States.
Diana E StanescuDivision of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
E Danielle DeanDivision of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, TN, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Pancreatic α cells are key regulators of glucose homeostasis, and dysregulated glucagon secretion contributes to hyperglycemia in diabetes. Amino acids strongly stimulate α-cell proliferation and glucagon release, yet the transport mechanisms underlying these responses remain incompletely defined. The neutral amino acid transporter SLC38A5 is highly enriched in α cells, but its α-cell-autonomous role in nutrient sensing is unclear. Methods: We generated an α-cell-specific Results: Conclusion: These data identify SLC38A5 as a mediator linking amino acid availability to α-cell proliferation, highlighting its role in α-cell nutrient sensing and adaptation.

Indexed as

Amino AcidsCell ProliferationGlucagonGlucagon-Secreting CellsAnimalsFemaleHumansMaleMiceMice, KnockoutSignal TransductionAmino AcidsGlucagonalpha cell proliferationamino acid transportglucagonmTORnutrient sensingpancreatic isletsSLC38A5

Identifiers

PMID42375320
PMCPMC13310714

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.